| Reaction Details |
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 | Report a problem with these data |
| Target | Breakpoint cluster region protein [1-693] |
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| Ligand | BDBM111460 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Assays |
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| IC50 | 542±n/a nM |
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| Citation |  Pan, X; Dong, J; Gao, H; Wang, F; Zhang, Y; Wang, S; Zhang, J Design, synthesis and biological evaluation of pyridin-3-yl pyrimidines as potent Bcr-Abl inhibitors. Chem Biol Drug Des83:592-9 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Breakpoint cluster region protein [1-693] |
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| Name: | Breakpoint cluster region protein [1-693] |
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| Synonyms: | BCR | BCR1 | BCR_HUMAN | Bcr-Abl | D22S11 |
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| Type: | Protein |
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| Mol. Mass.: | 76683.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11274[1-693] |
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| Residue: | 693 |
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| Sequence: | MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQ
TLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQPAPADGADPPPAEEPEARPDGE
GSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSC
GVDGDYEDAELNPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQ
STSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEG
AFHGDADGSFGTPPGYGCAADRAEEQRRHQDGLPYIDDSPSSSPHLSSKGRGSRDALVSG
ALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS
QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGV
AMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDL
LKHTPASHPDHPLLQDALRISQNFLSSINEEIT
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| BDBM111460 |
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| n/a |
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| Name | BDBM111460 |
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| Synonyms: | N-(3-acetylphenyl)-4-methyl-3-(4-(pyridin-3-yl) pyrimidin-2-ylamino) benzamide (A13) |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23N5O2 |
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| Mol. Mass. | 425.4824 |
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| SMILES | COCc1cccc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)c1 |
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| Structure | 
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