Reaction Details |
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Target | Breakpoint cluster region protein [1-693] |
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Ligand | BDBM111474 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Kinase Assays |
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IC50 | >1.00e+5±n/a nM |
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Citation | Pan, X; Dong, J; Gao, H; Wang, F; Zhang, Y; Wang, S; Zhang, J Design, synthesis and biological evaluation of pyridin-3-yl pyrimidines as potent Bcr-Abl inhibitors. Chem Biol Drug Des83:592-9 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Breakpoint cluster region protein [1-693] |
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Name: | Breakpoint cluster region protein [1-693] |
Synonyms: | BCR | BCR1 | BCR_HUMAN | Bcr-Abl | D22S11 |
Type: | Protein |
Mol. Mass.: | 76683.66 |
Organism: | Homo sapiens (Human) |
Description: | P11274[1-693] |
Residue: | 693 |
Sequence: | MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQ
TLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQPAPADGADPPPAEEPEARPDGE
GSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSC
GVDGDYEDAELNPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQ
STSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEG
AFHGDADGSFGTPPGYGCAADRAEEQRRHQDGLPYIDDSPSSSPHLSSKGRGSRDALVSG
ALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS
QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGV
AMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDL
LKHTPASHPDHPLLQDALRISQNFLSSINEEIT
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BDBM111474 |
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n/a |
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Name | BDBM111474 |
Synonyms: | 4-Methyl-N-(4-(3-morpholinopropoxy) phenyl)-3-(4-(pyridin-3-yl) pyrimidin-2-ylamino) benzamide (A27) |
Type | Small organic molecule |
Emp. Form. | C31H34N6O3 |
Mol. Mass. | 538.6401 |
SMILES | Cc1ccc(cc1Nc1nccc(n1)-c1cccnc1)C(=O)Nc1ccc(OCCCCN2CCOCC2)cc1 |
Structure |
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