| Reaction Details |
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 | Report a problem with these data |
| Target | TGF-beta receptor type-2 |
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| Ligand | BDBM283083 |
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| Substrate/Competitor | n/a |
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| IC50 | 2936±n/a nM |
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| Citation |  Kinsella, T; Gelman, M; Hong, H; Darwish, IS; Singh, R; Yu, J; Borzilleri, RM; Velaparthi, U; Liu, P; Darne, C; Rahaman, H; Warrier, JS TGF-beta inhibitors US Patent US9884868 Publication Date 2/6/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| TGF-beta receptor type-2 |
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| Name: | TGF-beta receptor type-2 |
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| Synonyms: | TGF-beta receptor type II | TGFBR2 | TGFR2_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64559.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_586859 |
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| Residue: | 567 |
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| Sequence: | MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFST
CDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPK
CIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAI
SVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTE
LLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLK
HENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAH
LHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVG
TARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVRE
HPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSE
LEHLDRLSGRSCSEEKIPEDGSLNTTK
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| BDBM283083 |
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| n/a |
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| Name | BDBM283083 |
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| Synonyms: | 6-(2-(4-fluorophenyl)-6,7-dihydro-5H-pyrrolo[1,2- a]imidazol-3-yl)imidazo[1,2-a]pyridine-3-carboxamide | US10287295, Example 283' | US11352360, Example 283' | US9884868, Example 283' |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16FN5O |
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| Mol. Mass. | 361.3723 |
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| SMILES | NC(=O)c1cnc2ccc(cn12)-c1c(nc2CCCn12)-c1ccc(F)cc1 |
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| Structure | 
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