| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin/Hypocretin receptor type 1 |
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| Ligand | BDBM119638 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Radioligand Binding |
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| Temperature | 277.15±n/a K |
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| Ki | 16±n/a nM |
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| Comments | extracted |
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| Citation |  Branstetter, BJ; Letavic, MA; Ly, KS; Rudolph, DA; Savall, BM; Shah, CR; Shireman, BT Fused heterocyclic compounds as orexin receptor modulators US Patent US8680275 Publication Date 3/25/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| Orexin/Hypocretin receptor type 1 |
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| Name: | Orexin/Hypocretin receptor type 1 |
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| Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
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| Type: | Protein |
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| Mol. Mass.: | 47554.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43613 |
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| Residue: | 425 |
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| Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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| BDBM119638 |
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| n/a |
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| Name | BDBM119638 |
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| Synonyms: | US8680275, 195 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23F3N4O |
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| Mol. Mass. | 452.4715 |
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| SMILES | Cc1ccc(c(c1)C(=O)N1CC[C@H]2CN([C@H]2C1)c1ccnc(n1)-c1ccccc1)C(F)(F)F |r| |
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| Structure | 
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