| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dihydrolipoyl dehydrogenase |
|---|
| Ligand | BDBM119876 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme Assays |
|---|
| Ki | 37±5 nM |
|---|
| Citation |  Bryk, R; Arango, N; Maksymiuk, C; Balakrishnan, A; Wu, YT; Wong, CH; Masquelin, T; Hipskind, P; Lima, CD; Nathan, C Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase. Biochemistry52:9375-84 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dihydrolipoyl dehydrogenase |
|---|
| Name: | Dihydrolipoyl dehydrogenase |
|---|
| Synonyms: | Component of peroxynitrite reductase/peroxidase complex | DLDH_MYCTO | Dihydrolipoyl dehydrogenase (Lpd) | Dihydrolipoyl dehydrogenase (Lpd) A181V | Dihydrolipoyl dehydrogenase (Lpd) A290R | Dihydrolipoyl dehydrogenase (Lpd) F269R | Dihydrolipoyl dehydrogenase (Lpd) G312A, L313G, L314P, Q315M | Dihydrolipoyl dehydrogenase (Lpd) L314P | Dihydrolipoyl dehydrogenase (Lpd) N209V | Dihydrolipoyl dehydrogenase (Lpd) R147T | Dihydrolipoyl dehydrogenase (Lpd) R347S | Lipoamide dehydrogenase (Lpd) | lpd | lpdC |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 49231.98 |
|---|
| Organism: | Mycobacterium tuberculosis |
|---|
| Description: | P9WHH8 |
|---|
| Residue: | 464 |
|---|
| Sequence: | MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCIPSKALLRNAELVH
IFTKDAKAFGISGEVTFDYGIAYDRSRKVAEGRVAGVHFLMKKNKITEIHGYGTFADANT
LLVDLNDGGTESVTFDNAIIATGSSTRLVPGTSLSANVVTYEEQILSRELPKSIIIAGAG
AIGMEFGYVLKNYGVDVTIVEFLPRALPNEDADVSKEIEKQFKKLGVTILTATKVESIAD
GGSQVTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKAGVALTDRKAIGVDDYMRTN
VGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGAETLTLGDHRMLPRATFCQPNVASFGL
TEQQARNEGYDVVVAKFPFTANAKAHGVGDPSGFVKLVADAKHGELLGGHLVGHDVAELL
PELTLAQRWDLTASELARNVHTHPTMSEALQECFHGLVGHMINF
|
|
|
|---|
| BDBM119876 |
|---|
| n/a |
|---|
| Name | BDBM119876 |
|---|
| Synonyms: | SL932 | US9073941, 503 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H16BrClN4O4S |
|---|
| Mol. Mass. | 463.734 |
|---|
| SMILES | COc1ccc(NC(=O)CN(C)S(=O)(=O)c2cc(Br)cnc2N)cc1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
