| Reaction Details |
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 | Report a problem with these data |
| Target | Hormone-sensitive lipase |
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| Ligand | BDBM121027 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| pH | 7.2±n/a |
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| Temperature | 277.15±n/a K |
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| IC50 | 42.1±n/a nM |
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| Comments | extracted |
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| Citation |  Hunziker, D; Neidhart, W SEC-hydroxycyclohexyl derivatives US Patent US8722721 Publication Date 5/13/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Hormone-sensitive lipase |
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| Name: | Hormone-sensitive lipase |
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| Synonyms: | HSL | Hormone sensitive lipase | Hormone-sensitive lipase (HSL) | LIPE | LIPS_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 116599.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q05469 |
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| Residue: | 1076 |
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| Sequence: | MEPGSKSVSRSDWQPEPHQRPITPLEPGPEKTPIAQPESKTLQGSNTQQKPASNQRPLTQ
QETPAQHDAESQKEPRAQQKSASQEEFLAPQKPAPQQSPYIQRVLLTQQEAASQQGPGLG
KESITQQEPALRQRHVAQPGPGPGEPPPAQQEAESTPAAQAKPGAKREPSAPTESTSQET
PEQSDKQTTPVQGAKSKQGSLTELGFLTKLQELSIQRSALEWKALSEWVTDSESESDVGS
SSDTDSPATMGGMVAQGVKLGFKGKSGYKVMSGYSGTSPHEKTSARNHRHYQDTASRLIH
NMDLRTMTQSLVTLAEDNIAFFSSQGPGETAQRLSGVFAGVREQALGLEPALGRLLGVAH
LFDLDPETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRTSHNLAELEAYLAALT
QLRALVYYAQRLLVTNRPGVLFFEGDEGLTADFLREYVTLHKGCFYGRCLGFQFTPAIRP
FLQTISIGLVSFGEHYKRNETGLSVAASSLFTSGRFAIDPELRGAEFERITQNLDVHFWK
AFWNITEMEVLSSLANMASATVRVSRLLSLPPEAFEMPLTADPTLTVTISPPLAHTGPGP
VLVRLISYDLREGQDSEELSSLIKSNGQRSLELWPRPQQAPRSRSLIVHFHGGGFVAQTS
RSHEPYLKSWAQELGAPIISIDYSLAPEAPFPRALEECFFAYCWAIKHCALLGSTGERIC
LAGDSAGGNLCFTVALRAAAYGVRVPDGIMAAYPATMLQPAASPSRLLSLMDPLLPLSVL
SKCVSAYAGAKTEDHSNSDQKALGMMGLVRRDTALLLRDFRLGASSWLNSFLELSGRKSQ
KMSEPIAEPMRRSVSEAALAQPQGPLGTDSLKNLTLRDLSLRGNSETSSDTPEMSLSAET
LSPSTPSDVNFLLPPEDAGEEAEAKNELSPMDRGLGVRAAFPEGFHPRRSSQGATQMPLY
SSPIVKNPFMSPLLAPDSMLKSLPPVHIVACALDPMLDDSVMLARRLRNLGQPVTLRVVE
DLPHGFLTLAALCRETRQAAELCVERIRLVLTPPAGAGPSGETGAAGVDGGCGGRH
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| BDBM121027 |
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| n/a |
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| Name | BDBM121027 |
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| Synonyms: | US8722721, 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19F6NO4 |
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| Mol. Mass. | 427.3382 |
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| SMILES | O[C@H]1CC[C@]2(CCN(C2=O)c2ccc(OC(F)(F)F)cc2)C[C@@H]1OCC(F)(F)F |r| |
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| Structure | 
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