| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 1 |
|---|
| Ligand | BDBM124220 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme Assays |
|---|
| IC50 | 5±0.0 nM |
|---|
| Citation |  Patel, D; Jain, M; Shah, SR; Bahekar, R; Jadav, P; Darji, B; Siriki, Y; Bandyopadhyay, D; Joharapurkar, A; Kshirsagar, S; Patel, H; Shaikh, M; Sairam, KV; Patel, P Discovery of orally active, potent, and selective benzotriazole-based PTP1B inhibitors. ChemMedChem6:1011-6 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein phosphatase non-receptor type 1 |
|---|
| Name: | Tyrosine-protein phosphatase non-receptor type 1 |
|---|
| Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) |
|---|
| Type: | Protein phosphatase |
|---|
| Mol. Mass.: | 49963.76 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human recombinant GST-fusion PTP1B (1-435). |
|---|
| Residue: | 435 |
|---|
| Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
|
|
|
|---|
| BDBM124220 |
|---|
| n/a |
|---|
| Name | BDBM124220 |
|---|
| Synonyms: | ({2-[2-(1H-1,2,3-benzotriazol-1-yl)-2-({6-bromo-7-[difluoro(phosphono)methyl]quinolin-2-yl}methyl)-3-oxo-3-phenylpropyl]-6-bromoquinolin-7-yl}difluoromethyl)phosphonic acid (10n) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C36H25Br2F4N5O7P2 |
|---|
| Mol. Mass. | 937.362 |
|---|
| SMILES | OP(O)(=O)C(F)(F)c1cc2nc(CC(Cc3ccc4cc(Br)c(cc4n3)C(F)(F)P(O)(O)=O)(C(=O)c3ccccc3)n3nnc4ccccc34)ccc2cc1Br |
|---|
| Structure | 
|
|---|
Search and Browse
