| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 1 |
|---|
| Ligand | BDBM127605 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Cell-Free Kinase Assays |
|---|
| pH | 7.5±n/a |
|---|
| IC50 | 3±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Gerlach, M; Seipelt, I; Blumenstein, L; Mueller, G; Guenther, E; Schuster, T; Teifel, M Pyridopyrazines as highly selective ras-Raf-Mek-Erk signal transduction pathway inhibitors US Patent US8791118 Publication Date 7/29/2014 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase 1 |
|---|
| Name: | Mitogen-activated protein kinase 1 |
|---|
| Synonyms: | ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK |
|---|
| Type: | Ser/Thr Protein Kinase |
|---|
| Mol. Mass.: | 41392.76 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P28482 |
|---|
| Residue: | 360 |
|---|
| Sequence: | MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
|
|
|
|---|
| BDBM127605 |
|---|
| n/a |
|---|
| Name | BDBM127605 |
|---|
| Synonyms: | US8791118, 168 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H34N8O2 |
|---|
| Mol. Mass. | 514.622 |
|---|
| SMILES | C[C@H](CCCc1ccccc1)NC(=O)Nc1ccc2ncc(nc2n1)-c1cnn(CCN2CCOCC2)c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
