Reaction Details |
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Target | C5a anaphylatoxin chemotactic receptor 1 |
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Ligand | BDBM134502 |
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Substrate/Competitor | n/a |
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Meas. Tech. | FLIPR Assay |
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IC50 | 2±n/a nM |
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Citation | Adams, CM; Darsigny, V; Flyer, AN; Gelin, CF; Hurley, TB; Ji, N; Karki, RG; Kawanami, T; Meredith, E; Rao, C; Serrano-Wu, MH; Solovay, CF Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5a receptor modulators US Patent US8846656 Publication Date 9/30/2014 |
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More Info.: | Get all data from this article, Assay Method |
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C5a anaphylatoxin chemotactic receptor 1 |
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Name: | C5a anaphylatoxin chemotactic receptor 1 |
Synonyms: | C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88 |
Type: | Enzyme |
Mol. Mass.: | 39347.68 |
Organism: | Homo sapiens (Human) |
Description: | P21730 |
Residue: | 350 |
Sequence: | MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVW
VTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNM
YASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREE
YFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKT
LKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIY
VVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
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BDBM134502 |
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n/a |
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Name | BDBM134502 |
Synonyms: | US8846656, 19-AI |
Type | Small organic molecule |
Emp. Form. | C34H44N6O |
Mol. Mass. | 552.7528 |
SMILES | CO[C@H]1CCN(CC1(C)C)c1nc(nc2CCN(Cc12)c1cc(ccc1C)C(C)C)-c1c(C)ccc2[nH]nc(C)c12 |r| |
Structure |
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