Reaction Details | |||
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Target | Tyrosine-protein kinase JAK3 | ||
Ligand | BDBM141464 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Assay | ||
pH | 8±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 62.7±n/a nM | ||
Comments | extracted | ||
Citation | Wrobleski, ST; Brown, GD; Doweyko, LM; Duan, J; Guo, J; Hynes, J; Jiang, B; Kempson, J; Lin, S; Lu, Z; Spergel, SH; Tokarski, JS; Wu, H; Yang, BV Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases US Patent US8921368 Publication Date 12/30/2014 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK3 | |||
Name: | Tyrosine-protein kinase JAK3 | ||
Synonyms: | JAK-3 | JAK3 | JAK3_HUMAN | Janus kinase 3 | Janus kinase 3 (JAK3) | Janus kinase 3 JAK3 | L-JAK | Leukocyte janus kinase | ||
Type: | Protein | ||
Mol. Mass.: | 125111.08 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P52333 | ||
Residue: | 1124 | ||
Sequence: |
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BDBM141464 | |||
n/a | |||
Name | BDBM141464 | ||
Synonyms: | US8921368, 162 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H24N6O2 | ||
Mol. Mass. | 368.4329 | ||
SMILES | Cn1nccc1-c1cc2c(N[C@H]3CC[C@@](C)(O)CC3)c(cnn2c1)C(N)=O |r,wU:11.11,14.16,wD:14.15,(-3.57,-4.75,;-4.34,-3.42,;-5.81,-2.95,;-5.81,-1.41,;-4.34,-.93,;-3.44,-2.18,;-1.9,-2.18,;-.99,-.93,;.47,-1.41,;1.81,-.64,;1.81,.9,;.47,1.67,;-.86,.9,;-2.19,1.67,;-2.19,3.21,;-3.53,3.98,;-2.19,4.75,;-.86,3.98,;.47,3.21,;3.14,-1.41,;3.14,-2.95,;1.81,-3.72,;.47,-2.95,;-.99,-3.42,;4.47,-.64,;5.81,-1.41,;4.47,.9,)| | ||
Structure |