Reaction Details | |||
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Target | Tyrosine-protein kinase JAK3 | ||
Ligand | BDBM141465 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Assay | ||
pH | 8±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 33.6±n/a nM | ||
Comments | extracted | ||
Citation | Wrobleski, ST; Brown, GD; Doweyko, LM; Duan, J; Guo, J; Hynes, J; Jiang, B; Kempson, J; Lin, S; Lu, Z; Spergel, SH; Tokarski, JS; Wu, H; Yang, BV Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases US Patent US8921368 Publication Date 12/30/2014 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK3 | |||
Name: | Tyrosine-protein kinase JAK3 | ||
Synonyms: | JAK-3 | JAK3 | JAK3_HUMAN | Janus kinase 3 | Janus kinase 3 (JAK3) | Janus kinase 3 JAK3 | L-JAK | Leukocyte janus kinase | ||
Type: | Protein | ||
Mol. Mass.: | 125111.08 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P52333 | ||
Residue: | 1124 | ||
Sequence: |
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BDBM141465 | |||
n/a | |||
Name | BDBM141465 | ||
Synonyms: | US8921368, 166 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H25N5O3 | ||
Mol. Mass. | 407.4656 | ||
SMILES | C[C@@]1(O)CC[C@@H](CC1)Nc1c(cnn2cc(cc12)-c1ccccc1C(N)=O)C(N)=O |r,wU:5.8,1.1,wD:1.0,(-3.17,4.7,;-1.84,3.93,;-1.84,5.47,;-1.84,2.39,;-.51,1.62,;.83,2.39,;.83,3.93,;-.51,4.7,;2.16,1.62,;2.16,.08,;3.49,-.69,;3.49,-2.23,;2.16,-3,;.83,-2.23,;-.64,-2.71,;-1.54,-1.46,;-.64,-.22,;.83,-.69,;-3.08,-1.46,;-3.85,-.13,;-5.39,-.13,;-6.16,-1.46,;-5.39,-2.8,;-3.82,-2.85,;-3.05,-4.18,;-3.82,-5.51,;-1.51,-4.18,;4.83,.08,;6.16,-.69,;4.83,1.62,)| | ||
Structure |