Reaction Details | |||
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Target | Tyrosine-protein kinase JAK3 | ||
Ligand | BDBM141470 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Assay | ||
pH | 8±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 1±n/a nM | ||
Comments | extracted | ||
Citation | Wrobleski, ST; Brown, GD; Doweyko, LM; Duan, J; Guo, J; Hynes, J; Jiang, B; Kempson, J; Lin, S; Lu, Z; Spergel, SH; Tokarski, JS; Wu, H; Yang, BV Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases US Patent US8921368 Publication Date 12/30/2014 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK3 | |||
Name: | Tyrosine-protein kinase JAK3 | ||
Synonyms: | JAK-3 | JAK3 | JAK3_HUMAN | Janus kinase 3 | Janus kinase 3 (JAK3) | Janus kinase 3 JAK3 | L-JAK | Leukocyte janus kinase | ||
Type: | Protein | ||
Mol. Mass.: | 125111.08 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P52333 | ||
Residue: | 1124 | ||
Sequence: |
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BDBM141470 | |||
n/a | |||
Name | BDBM141470 | ||
Synonyms: | US8921368, 178 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H28N4O3 | ||
Mol. Mass. | 432.5148 | ||
SMILES | COc1ccccc1-c1cc2c(NC3C4CC5CC3CC(O)(C5)C4)c(cnn2c1)C(N)=O |TLB:21:20:13:15.16.17,12:13:15:20.22.23,12:13:20.19.23:15.16.17,THB:22:20:13:15.16.17,22:16:13:20.19.23,19:20:15:13.18.17,19:18:15:20.22.23,(-1.54,-5.36,;-3.08,-5.36,;-3.85,-4.03,;-5.39,-4.03,;-6.16,-2.7,;-5.39,-1.36,;-3.85,-1.36,;-3.08,-2.7,;-1.54,-2.7,;-.64,-1.45,;.83,-1.93,;2.16,-1.16,;2.16,.38,;.83,1.15,;-.01,3.05,;-.01,4.59,;-1.34,5.36,;-.58,4.2,;-.57,1.8,;-1.77,1.13,;-2.67,3.05,;-4,2.28,;-2.67,4.59,;-1.34,2.28,;3.49,-1.93,;3.49,-3.47,;2.16,-4.24,;.83,-3.47,;-.64,-3.94,;4.83,-1.16,;6.16,-1.93,;4.83,.38,)| | ||
Structure |