Reaction Details | |||
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Target | Tyrosine-protein kinase JAK3 | ||
Ligand | BDBM141471 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Assay | ||
pH | 8±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 6.2±n/a nM | ||
Comments | extracted | ||
Citation | Wrobleski, ST; Brown, GD; Doweyko, LM; Duan, J; Guo, J; Hynes, J; Jiang, B; Kempson, J; Lin, S; Lu, Z; Spergel, SH; Tokarski, JS; Wu, H; Yang, BV Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases US Patent US8921368 Publication Date 12/30/2014 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK3 | |||
Name: | Tyrosine-protein kinase JAK3 | ||
Synonyms: | JAK-3 | JAK3 | JAK3_HUMAN | Janus kinase 3 | Janus kinase 3 (JAK3) | Janus kinase 3 JAK3 | L-JAK | Leukocyte janus kinase | ||
Type: | Protein | ||
Mol. Mass.: | 125111.08 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P52333 | ||
Residue: | 1124 | ||
Sequence: |
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BDBM141471 | |||
n/a | |||
Name | BDBM141471 | ||
Synonyms: | US8921368, 185 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H26N6O2 | ||
Mol. Mass. | 406.4808 | ||
SMILES | Cn1nccc1-c1cc2c(NC3C4CC5CC3CC(O)(C5)C4)c(cnn2c1)C(N)=O |TLB:19:18:11:13.14.15,10:11:13:18.20.21,10:11:18.17.21:13.14.15,THB:20:18:11:13.14.15,20:14:11:18.17.21,17:18:13:11.16.15,17:16:13:18.20.21,(-3.57,-5.32,;-4.34,-3.99,;-5.81,-3.51,;-5.81,-1.97,;-4.34,-1.49,;-3.44,-2.74,;-1.9,-2.74,;-.99,-1.49,;.47,-1.97,;1.81,-1.2,;1.81,.34,;.47,1.11,;-.36,3.01,;-.36,4.55,;-1.69,5.32,;-.94,4.15,;-.92,1.75,;-2.13,1.09,;-3.02,3.01,;-4.36,2.24,;-3.02,4.55,;-1.69,2.24,;3.14,-1.97,;3.14,-3.51,;1.81,-4.28,;.47,-3.51,;-.99,-3.99,;4.47,-1.2,;5.81,-1.97,;4.47,.34,)| | ||
Structure |