Reaction Details | |||
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Target | Tyrosine-protein kinase JAK3 | ||
Ligand | BDBM141472 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Assay | ||
pH | 8±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 6.1±n/a nM | ||
Comments | extracted | ||
Citation | Wrobleski, ST; Brown, GD; Doweyko, LM; Duan, J; Guo, J; Hynes, J; Jiang, B; Kempson, J; Lin, S; Lu, Z; Spergel, SH; Tokarski, JS; Wu, H; Yang, BV Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases US Patent US8921368 Publication Date 12/30/2014 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK3 | |||
Name: | Tyrosine-protein kinase JAK3 | ||
Synonyms: | JAK-3 | JAK3 | JAK3_HUMAN | Janus kinase 3 | Janus kinase 3 (JAK3) | Janus kinase 3 JAK3 | L-JAK | Leukocyte janus kinase | ||
Type: | Protein | ||
Mol. Mass.: | 125111.08 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P52333 | ||
Residue: | 1124 | ||
Sequence: |
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BDBM141472 | |||
n/a | |||
Name | BDBM141472 | ||
Synonyms: | US8921368, 187 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H28N4O2 | ||
Mol. Mass. | 416.5154 | ||
SMILES | Cc1ccc(cc1)-c1cc2c(NC3C4CC5CC3CC(O)(C5)C4)c(cnn2c1)C(N)=O |TLB:20:19:12:14.15.16,11:12:14:19.21.22,11:12:19.18.22:14.15.16,THB:21:19:12:14.15.16,21:15:12:19.18.22,18:19:14:12.17.16,18:17:14:19.21.22,(-6.93,-3.26,;-5.39,-3.26,;-4.62,-1.93,;-3.08,-1.93,;-2.31,-3.26,;-3.08,-4.59,;-4.62,-4.59,;-.77,-3.26,;.13,-2.01,;1.6,-2.49,;2.93,-1.72,;2.93,-.18,;1.6,.59,;.76,2.49,;.76,4.03,;-.57,4.8,;.19,3.63,;.2,1.23,;-1,.57,;-1.9,2.49,;-3.23,1.72,;-1.9,4.03,;-.57,1.72,;4.26,-2.49,;4.26,-4.03,;2.93,-4.8,;1.6,-4.03,;.13,-4.51,;5.6,-1.72,;6.93,-2.49,;5.6,-.18,)| | ||
Structure |