Reaction Details | |||
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Target | Tyrosine-protein kinase JAK1 | ||
Ligand | BDBM141467 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Assay | ||
pH | 7.4±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 105.1±n/a nM | ||
Comments | extracted | ||
Citation | Wrobleski, ST; Brown, GD; Doweyko, LM; Duan, J; Guo, J; Hynes, J; Jiang, B; Kempson, J; Lin, S; Lu, Z; Spergel, SH; Tokarski, JS; Wu, H; Yang, BV Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases US Patent US8921368 Publication Date 12/30/2014 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK1 | |||
Name: | Tyrosine-protein kinase JAK1 | ||
Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
Type: | Protein | ||
Mol. Mass.: | 133293.73 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P23458 | ||
Residue: | 1154 | ||
Sequence: |
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BDBM141467 | |||
n/a | |||
Name | BDBM141467 | ||
Synonyms: | US8921368, 168 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H22N6O2 | ||
Mol. Mass. | 366.417 | ||
SMILES | C[C@@]1(O)CC[C@@H](CC1)Nc1c(cnn2cc(cc12)-c1cncnc1)C(N)=O |r,wU:5.8,1.1,wD:1.0,(-3.17,3.47,;-1.84,2.69,;-1.84,4.23,;-1.84,1.15,;-.51,.38,;.83,1.15,;.83,2.69,;-.51,3.47,;2.16,.38,;2.16,-1.15,;3.49,-1.93,;3.49,-3.47,;2.16,-4.23,;.83,-3.47,;-.64,-3.94,;-1.54,-2.69,;-.64,-1.45,;.83,-1.93,;-3.08,-2.69,;-3.85,-1.36,;-5.39,-1.36,;-6.16,-2.69,;-5.39,-4.03,;-3.85,-4.03,;4.83,-1.15,;6.16,-1.93,;4.83,.38,)| | ||
Structure |