Reaction Details |
| Report a problem with these data |
Target | Coagulation factor XI |
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Ligand | BDBM285950 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Factor XIa Assay |
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pH | 7.4±n/a |
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IC50 | 2.04±n/a nM |
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Comments | extracted |
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Citation | Mertz, E; Edmondson, SD; So, S; Sun, W; Liu, W; Neelamkavil, SF; Gao, Y; Hruza, A; Zang, Y; Ali, A; Mal, R; He, J; Kuang, R; Wu, H; Ogawa, AK; Nolting, AF Factor XIa inhibitors US Patent US10081617 Publication Date 9/25/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Coagulation factor XI |
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Name: | Coagulation factor XI |
Synonyms: | Coagulation factor XIa | Coagulation factor XIa heavy chain | Coagulation factor XIa light chain | F11 | FA11_HUMAN | FXI | Factor XIa | Factor XIa (fXIa) | PTA | Plasma thromboplastin antecedent |
Type: | Enzyme |
Mol. Mass.: | 70130.58 |
Organism: | Homo sapiens (Human) |
Description: | P03951 |
Residue: | 625 |
Sequence: | MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFT
FTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDM
KGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITK
LDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFT
FFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTD
FLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKIL
HGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSI
IGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYD
IALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLV
TNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCA
QRERPGVYTNVVEYVDWILEKTQAV
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BDBM285950 |
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n/a |
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Name | BDBM285950 |
Synonyms: | US10081617, Example 97 | methyl [3-chloro-4-(2-{3-[5- chloro-2-(4-cyano-1H-1,2,3- triazol-1-yl)phenyl]-7-hydroxy- 1-oxido-6,7-dihydro-5H- cyclopenta[b]pyridin-7-yl}-1H- imidazol-4-yl)phenyl]carbamate |
Type | Small organic molecule |
Emp. Form. | C28H20Cl2N8O4 |
Mol. Mass. | 603.416 |
SMILES | COC(=O)Nc1ccc(-c2c[nH]c(n2)C2(O)CCc3cc(c[n+]([O-])c23)-c2cc(Cl)ccc2-n2cc(nn2)C#N)c(Cl)c1 |
Structure |
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