Reaction Details |
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Target | Neuraminidase |
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Ligand | BDBM4932 |
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Substrate/Competitor | BDBM4702 |
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Meas. Tech. | Neuraminidase Inhibition Assay |
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pH | 6.5±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 25±n/a nM |
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Citation | Smith, PW; Sollis, SL; Howes, PD; Cherry, PC; Starkey, ID; Cobley, KN; Weston, H; Scicinski, J; Merritt, A; Whittington, A; Wyatt, P; Taylor, N; Green, D; Bethell, R; Madar, S; Fenton, RJ; Morley, PJ; Pateman, T; Beresford, A Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4H-pyran-6-carboxamides. J Med Chem41:787-97 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Neuraminidase |
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Name: | Neuraminidase |
Synonyms: | Influenza A Virus Neuraminidase | NA | NRAM_I57A5 | Neuraminidase A |
Type: | Enzyme |
Mol. Mass.: | 52000.86 |
Organism: | Influenza A virus (A/Singapore/1/57(H2N2)) |
Description: | Q6XUE4 |
Residue: | 469 |
Sequence: | MNPNQKIITIGSVSLTIATVCFLMQIAILATTVTLHFKQHECDSPASNQVMPCEPIIIER
NITEIVYLNNTTIEKEICPEVVEYRNWSKPQCQITGFAPFSKDNSIRLSAGGDIWVTREP
YVSCDPGKCYQFALGQGTTLDNKHSNGTIHDRIPHRTLLMNELGVPFHLGTKQVCVAWSS
SSCHDGKAWLHVCVTGDDRNATASFIYDGRLVDSIGSWSQNILRTQESECVCINGTCTVV
MTDGSASGRADTRILFIKEGKIVHISPLSGSAQHIEECSCYPRYPDVRCICRDNWKGSNR
PVIDINMEDYSIDSSYVCSGLVGDTPRNDDSSSNSNCRDPNNERGNPGVKGWAFDNGDDV
WMGRTINKDSRSGYETFKVIGGWSTPNSKSQVNRQVIVDNNNWSGYSGIFSVEGKSCINR
CFYVELIRGRPQETRVWWTSNSIVVFCGTSGTYGTGSWPDGANINFMPI
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BDBM4932 |
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BDBM4702 |
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Name | BDBM4932 |
Synonyms: | (2R,3R,4S)-4-carbamimidamido-2-(dimethylcarbamoyl)-3-acetamido-3,4-dihydro-2H-pyran-6-carboxylic acid | carboxamide deriv. 5e |
Type | Small organic molecule |
Emp. Form. | C12H19N5O5 |
Mol. Mass. | 313.3098 |
SMILES | [H][C@]1([#8]-[#6](=[#6]-[#6@H](\[#7]=[#6](/[#7])-[#7])-[#6@H]1-[#7]-[#6](-[#6])=O)-[#6](-[#8])=O)[#6](=O)-[#7](-[#6])-[#6] |r,c:3| |
Structure |
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