Reaction Details |
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Target | Neuraminidase |
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Ligand | BDBM4941 |
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Substrate/Competitor | BDBM4702 |
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Meas. Tech. | Neuraminidase Inhibition Assay |
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IC50 | 410±n/a nM |
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Citation | Smith, PW; Sollis, SL; Howes, PD; Cherry, PC; Starkey, ID; Cobley, KN; Weston, H; Scicinski, J; Merritt, A; Whittington, A; Wyatt, P; Taylor, N; Green, D; Bethell, R; Madar, S; Fenton, RJ; Morley, PJ; Pateman, T; Beresford, A Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4H-pyran-6-carboxamides. J Med Chem41:787-97 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Neuraminidase |
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Name: | Neuraminidase |
Synonyms: | Influenza B Virus Neuraminidase | NA | NRAM_INBVI | Neuraminidase B |
Type: | Enzyme |
Mol. Mass.: | 51459.76 |
Organism: | Influenza B virus |
Description: | n/a |
Residue: | 465 |
Sequence: | MLPSTIQTLTLFLTSGGVLLSLYVSASLSYLLYSDILLKFSPKITAPTMTLDCTNASNVQ
AVNRSATKEMTFLLPEPEWTYPRLSCQGSTFQKALLISPHRFGEARGNSAPLIIREPFIA
CGPKECKHFALTHYAAQPGGYYNGTREDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSA
CHDGREWTYIGVDGPDSNALIKIKYGEAYTDTYHSYANNILRTQESACNCIGGDCYLMIT
DGSASGISKCRFLKIREGRIIKEIFPTGRVEHTEECTCGFASNKTIECACRDNNYTAKRP
FVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGRGGIKGGFVHQRMASKI
GRWYSRTMSKTERMGMELYVKYDGDPWTDSDALDPSGVMVSIKEPGWYSFGFEIKDKKCD
VPCIGIEMVHDGGKKTWHSAATAIYCLMGSGQLLWDTVTGVDMAL
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BDBM4941 |
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BDBM4702 |
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Name | BDBM4941 |
Synonyms: | (2R,3R,4S)-4-amino-3-acetamido-2-[ethyl(propyl)carbamoyl]-3,4-dihydro-2H-pyran-6-carboxylic acid | carboxamide deriv. 4m |
Type | Small organic molecule |
Emp. Form. | C14H23N3O5 |
Mol. Mass. | 313.3495 |
SMILES | [H][C@]1(OC(=C[C@H](N)[C@H]1NC(C)=O)C(O)=O)C(=O)N(CC)CCC |r,c:3| |
Structure |
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