Reaction Details |
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Target | Translocator protein |
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Ligand | BDBM150164 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Competitive Binding Assay |
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Temperature | 303.15±n/a K |
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Ki | 7.17±n/a nM |
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IC50 | 16.86±n/a nM |
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Comments | extracted |
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Citation | Yang, R; Li, Y; Li, Y; Zhao, N; Yun, L; Qin, J; Feng, Z; Zhang, Y 2-aryl imidazo[1,2-a]pyridine-3-acetamide derivatives, preparation methods and uses thereof US Patent US8980887 Publication Date 3/17/2015 |
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More Info.: | Get all data from this article, Assay Method |
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Translocator protein |
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Name: | Translocator protein |
Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
Type: | Mitochondrion membrane protein |
Mol. Mass.: | 18945.84 |
Organism: | Rattus norvegicus (rat) |
Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
Residue: | 169 |
Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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BDBM150164 |
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n/a |
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Name | BDBM150164 |
Synonyms: | US8980887, Compound 1 |
Type | Small organic molecule |
Emp. Form. | C25H24ClN3O |
Mol. Mass. | 417.931 |
SMILES | CCN(Cc1ccccc1)C(=O)Cc1c(nc2cc(C)ccn12)-c1ccc(Cl)cc1 |
Structure |
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