| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nitric oxide synthase, inducible |
|---|
| Ligand | BDBM152698 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Hemoglobin Assay |
|---|
| pH | 7.4±n/a |
|---|
| Ki | 1.8e+2±n/a nM |
|---|
| IC50 | 4e+2±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Tang, W; Li, H; Poulos, TL; Silverman, RB Mechanistic studies of inactivation of inducible nitric oxide synthase by amidines. Biochemistry54:2530-8 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nitric oxide synthase, inducible |
|---|
| Name: | Nitric oxide synthase, inducible |
|---|
| Synonyms: | Inducible NO synthase | Inducible NOS | Inducible nitric oxide synthase (iNOS) | Inosl | MAC-NOS | Macrophage NOS | NOS type II | NOS2_MOUSE | Nitric Oxide Synthase, inducible | Nitric oxide synthase, inducible (iNOS) | Nos2 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 130595.79 |
|---|
| Organism: | Mus musculus (mouse) |
|---|
| Description: | Recombinant enzyme overexpressed in E. coli. |
|---|
| Residue: | 1144 |
|---|
| Sequence: | MACPWKFLFKVKSYQSDLKEEKDINNNVKKTPCAVLSPTIQDDPKSHQNGSPQLLTGTAQ
NVPESLDKLHVTSTRPQYVRIKNWGSGEILHDTLHHKATSDFTCKSKSCLGSIMNPKSLT
RGPRDKPTPLEELLPHAIEFINQYYGSFKEAKIEEHLARLEAVTKEIETTGTYQLTLDEL
IFATKMAWRNAPRCIGRIQWSNLQVFDARNCSTAQEMFQHICRHILYATNNGNIRSAITV
FPQRSDGKHDFRLWNSQLIRYAGYQMPDGTIRGDAATLEFTQLCIDLGWKPRYGRFDVLP
LVLQADGQDPEVFEIPPDLVLEVTMEHPKYEWFQELGLKWYALPAVANMLLEVGGLEFPA
CPFNGWYMGTEIGVRDFCDTQRYNILEEVGRRMGLETHTLASLWKDRAVTEINVAVLHSF
QKQNVTIMDHHTASESFMKHMQNEYRARGGCPADWIWLVPPVSGSITPVFHQEMLNYVLS
PFYYYQIEPWKTHIWQNEKLRPRRREIRFRVLVKVVFFASMLMRKVMASRVRATVLFATE
TGKSEALARDLATLFSYAFNTKVVCMDQYKASTLEEEQLLLVVTSTFGNGDCPSNGQTLK
KSLFMLRELNHTFRYAVFGLGSSMYPQFCAFAHDIDQKLSHLGASQLAPTGEGDELSGQE
DAFRSWAVQTFRAACETFDVRSKHHIQIPKRFTSNATWEPQQYRLIQSPEPLDLNRALSS
IHAKNVFTMRLKSQQNLQSEKSSRTTLLVQLTFEGSRGPSYLPGEHLGIFPGNQTALVQG
ILERVVDCPTPHQTVCLEVLDESGSYWVKDKRLPPCSLSQALTYFLDITTPPTQLQLHKL
ARFATDETDRQRLEALCQPSEYNDWKFSNNPTFLEVLEEFPSLHVPAAFLLSQLPILKPR
YYSISSSQDHTPSEVHLTVAVVTYRTRDGQGPLHHGVCSTWIRNLKPQDPVPCFVRSVSG
FQLPEDPSQPCILIGPGTGIAPFRSFWQQRLHDSQHKGLKGGRMSLVFGCRHPEEDHLYQ
EEMQEMVRKRVLFQVHTGYSRLPGKPKVYVQDILQKQLANEVLSVLHGEQGHLYICGDVR
MARDVATTLKKLVATKLNLSEEQVEDYFFQLKSQKRYHEDIFGAVFSYGAKKGSALEEPK
ATRL
|
|
|
|---|
| BDBM152698 |
|---|
| n/a |
|---|
| Name | BDBM152698 |
|---|
| Synonyms: | (S)-2-Amino-5-formimidamidopentanoic acid (7) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C6H13N3O2 |
|---|
| Mol. Mass. | 159.1863 |
|---|
| SMILES | N[C@@H](CCCNC=N)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
