| Reaction Details |
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 | Report a problem with these data |
| Target | Urease [D459Y,K653P] |
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| Ligand | BDBM152762 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In vitro Urease Inhibition Assay |
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| pH | 8.2±n/a |
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| IC50 | 3.23e+3± 3.6e+2 nM |
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| Comments | extracted |
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| Citation |  Saeed, A; Imran, A; Channar, PA; Shahid, M; Mahmood, W; Iqbal, J 2-(Hetero(aryl)methylene)hydrazine-1-carbothioamides as potent urease inhibitors. Chem Biol Drug Des85:225-30 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urease [D459Y,K653P] |
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| Name: | Urease [D459Y,K653P] |
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| Synonyms: | UREA_CANEN | Urea amidohydrolase | Urease |
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| Type: | Protein |
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| Mol. Mass.: | 90763.23 |
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| Organism: | Canavalia ensiformis (Jack bean) |
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| Description: | P07374[D459Y,K653P] |
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| Residue: | 840 |
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| Sequence: | MKLSPREVEKLGLHNAGYLAQKRLARGVRLNYTEAVALIASQIMEYARDGEKTVAQLMCL
GQHLLGRRQVLPAVPHLLNAVQVEATFPDGTKLVTVHDPISRENGELQEALFGSLLPVPS
LDKFAETKEDNRIPGEILCEDECLTLNIGRKAVILKVTSKGDRPIQVGSHYHFIEVNPYL
TFDRRKAYGMRLNIAAGTAVRFEPGDCKSVTLVSIEGNKVIRGGNAIADGPVNETNLEAA
MHAVRSKGFGHEEEKDASEGFTKEDPNCPFNTFIHRKEYANKYGPTTGDKIRLGDTNLLA
EIEKDYALYGDECVFGGGKVIRDGMGQSCGHPPAISLDTVITNAVIIDYTGIIKADIGIK
DGLIASIGKAGNPDIMNGVFSNMIIGANTEVIAGEGLIVTAGAIDCHVHYICPQLVYEAI
SSGITTLVGGGTGPAAGTRATTCTPSPTQMRLMLQSTDYLPLNFGFTGKGSSSKPDELHE
IIKAGAMGLKLHEDWGSTPAAIDNCLTIAEHHDIQINIHTDTLNEAGFVEHSIAAFKGRT
IHTYHSEGAGGGHAPDIIKVCGIKNVLPSSTNPTRPLTSNTIDEHLDMLMVCHHLDREIP
EDLAFAHSRIRKKTIAAEDVLNDIGAISIISSDSQAMGRVGEVISRTWQTADPMKAQTGP
LKCDSSDNDNFRIRRYIAKYTINPAIANGFSQYVGSVEVGKLADLVMWKPSFFGTKPEMV
IKGGMVAWADIGDPNASIPTPEPVKMRPMYGTLGKAGGALSIAFVSKAALDQRVNVLYGL
NKRVEAVSNVRKLTKLDMKLNDALPEITVDPESYTVKADGKLLCVSEATTVPLSRNYFLF
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| BDBM152762 |
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| n/a |
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| Name | BDBM152762 |
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| Synonyms: | [(E)-[2-(5-methylfuran-2-yl)ethylidene]amino]thiourea (3g) |
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| Type | Small organic molecule |
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| Emp. Form. | C8H11N3OS |
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| Mol. Mass. | 197.257 |
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| SMILES | Cc1ccc(C\C=N\NC(N)=S)o1 |
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| Structure | 
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