| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase TBK1 |
|---|
| Ligand | BDBM50085411 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | KinEASE-STK Assay |
|---|
| IC50 | 282± 8 nM |
|---|
| Citation |  Richters, A; Basu, D; Engel, J; Ercanoglu, MS; Balke-Want, H; Tesch, R; Thomas, RK; Rauh, D Identification and further development of potent TBK1 inhibitors. ACS Chem Biol10:289-98 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase TBK1 |
|---|
| Name: | Serine/threonine-protein kinase TBK1 |
|---|
| Synonyms: | NAK | NF-kappa-B-activating kinase | Protein cereblon/Serine/threonine-protein kinase TBK1 | T2K | TANK-binding kinase 1 (TBK-1) | TANK-binding kinase 1 (TBK1) | TBK1 | TBK1_HUMAN |
|---|
| Type: | protein |
|---|
| Mol. Mass.: | 83645.20 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UHD2 |
|---|
| Residue: | 729 |
|---|
| Sequence: | MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK
KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL
HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA
ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV
LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG
VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK
VYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQE
GTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTH
FTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQ
KMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD
GGLRNVDCL
|
|
|
|---|
| BDBM50085411 |
|---|
| n/a |
|---|
| Name | BDBM50085411 |
|---|
| Synonyms: | 3-[1-(3,5-Dichloro-4-hydroxy-phenyl)-meth-(Z)-ylidene]-5-(furan-2-carbonyl)-1,3-dihydro-indol-2-one | CHEMBL73157 | GSK screening, 31 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H11Cl2NO4 |
|---|
| Mol. Mass. | 400.212 |
|---|
| SMILES | Oc1c(Cl)cc(\C=C2/C(=O)Nc3ccc(cc23)C(=O)c2ccco2)cc1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
