| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Phospholipase D1 |
|---|
| Ligand | BDBM75441 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In vitro Exogenous Substrate Assay |
|---|
| pH | 7.5±n/a |
|---|
| IC50 | 7.6e+3± 2.2e+3 nM |
|---|
| Comments | extracted |
|---|
| Citation |  Scott, SA; Spencer, CT; O'Reilly, MC; Brown, KA; Lavieri, RR; Cho, CH; Jung, DI; Larock, RC; Brown, HA; Lindsley, CW Discovery of desketoraloxifene analogues as inhibitors of mammalian, Pseudomonas aeruginosa, and NAPE phospholipase D enzymes. ACS Chem Biol10:421-32 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Phospholipase D1 |
|---|
| Name: | Phospholipase D1 |
|---|
| Synonyms: | Choline phosphatase 1 | PLD 1 | PLD1 | PLD1_HUMAN | Phosphatidylcholine-hydrolyzing phospholipase D1 | Phospholipase D (PLD) | Phospholipase D1 | Phospholipase D1 (PLD1) | Phospholipase D2 (PLD2) | hPLD1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 124219.92 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q13393 |
|---|
| Residue: | 1074 |
|---|
| Sequence: | MSLKNEPRVNTSALQKIAADMSNIIENLDTRELHFEGEEVDYDVSPSDPKIQEVYIPFSA
IYNTQGFKEPNIQTYLSGCPIKAQVLEVERFTSTTRVPSINLYTIELTHGEFKWQVKRKF
KHFQEFHRELLKYKAFIRIPIPTRRHTFRRQNVREEPREMPSLPRSSENMIREEQFLGRR
KQLEDYLTKILKMPMYRNYHATTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNC
CGQGRACYRWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRID
NLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNFLKDHRFGSYAAIQENALAKWYVNAKG
YFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLY
KEVELALGINSEYTKRTLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGI
DLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPPAAMESMESLRLKDKNEPVQNLPIQKS
IDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSSYFNHYRSHHNLIHGL
KPHFKLFHPSSESEQGLTRPHADTGSIRSLQTGVGELHGETRFWHGKDYCNFVFKDWVQL
DKPFADFIDRYSTPRMPWHDIASAVHGKAARDVARHFIQRWNFTKIMKSKYRSLSYPFLL
PKSQTTAHELRYQVPGSVHANVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIE
NQFFISCADDKVVFNKIGDAIAQRILKAHRENQKYRVYVVIPLLPGFEGDISTGGGNALQ
AIMHFNYRTMCRGENSILGQLKAELGNQWINYISFCGLRTHAELEGNLVTELIYVHSKLL
IADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARGLRLQCF
RVVLGYLDDPSEDIQDPVSDKFFKEVWVSTAARNATIYDKVFRCLPNDEVHNLIQLRDFI
NKPVLAKEDPIRAEEELKKIRGFLVQFPFYFLSEESLLPSVGTKEAIVPMEVWT
|
|
|
|---|
| BDBM75441 |
|---|
| n/a |
|---|
| Name | BDBM75441 |
|---|
| Synonyms: | 1-[2-[4-[2-(3-methoxyphenyl)-1-benzothiophen-3-yl]phenoxy]ethyl]pyrrolidine | 1-[2-[4-[2-(3-methoxyphenyl)benzothiophen-3-yl]phenoxy]ethyl]pyrrolidine | 22GK (17c) | MLS002473628 | SMR001397795 | cid_44202271 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H27NO2S |
|---|
| Mol. Mass. | 429.574 |
|---|
| SMILES | COc1cccc(c1)-c1sc2ccccc2c1-c1ccc(OCCN2CCCC2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
