Compile Data Set for Download or QSAR

Found 132 hits with Last Name = 'lavieri' and Initial = 'rr'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phospholipase D1 (Homo sapiens (Human))	BDBM87119 ((1R,2R)-N-[(1S)-2-[4-(5-bromo-2-keto-3H-benzimidaz...) Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)[C@@H]1C[C@H]1c1ccccc1 Show InChI InChI=1S/C25H29BrN4O2/c1-16(27-24(31)21-14-20(21)17-5-3-2-4-6-17)15-29-11-9-19(10-12-29)30-23-8-7-18(26)13-22(23)28-25(30)32/h2-8,13,16,19-21H,9-12,14-15H2,1H3,(H,27,31)(H,28,32)/t16-,20-,21+/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University					Assay Description Cells were seeded into 12-well tissue culture plates to reach 90% confluence at the time of assay. All cell types, aside from the HEK293-gfpPLD2 cell...				ACS Chem Biol 10: 421-32 (2015) Article DOI: 10.1021/cb500828m BindingDB Entry DOI: 10.7270/Q2H70DK8
					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM154517 (ML299 (5)) Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1cccc(F)c1)NC(=O)c1ccc(Br)cc1 Show InChI InChI=1S/C23H26BrFN4O2/c1-16(27-21(30)17-5-7-18(24)8-6-17)14-28-11-9-23(10-12-28)22(31)26-15-29(23)20-4-2-3-19(25)13-20/h2-8,13,16H,9-12,14-15H2,1H3,(H,26,31)(H,27,30)/t16-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University					Assay Description Cells were seeded into 12-well tissue culture plates to reach 90% confluence at the time of assay. All cell types, aside from the HEK293-gfpPLD2 cell...				ACS Chem Biol 10: 421-32 (2015) Article DOI: 10.1021/cb500828m BindingDB Entry DOI: 10.7270/Q2H70DK8
					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM50326960 ((S)-N-(1-(1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspi...) Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1cccc(F)c1)NC(=O)c1ccc2ccccc2c1 |r| Show InChI InChI=1S/C27H29FN4O2/c1-19(30-25(33)22-10-9-20-5-2-3-6-21(20)15-22)17-31-13-11-27(12-14-31)26(34)29-18-32(27)24-8-4-7-23(28)16-24/h2-10,15-16,19H,11-14,17-18H2,1H3,(H,29,34)(H,30,33)/t19-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of PLD1 in human calu1 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM50258182 ((S)-N-(1-(4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzo[d...) Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O)NC(=O)c1ccc2ccccc2c1 |r| Show InChI InChI=1S/C26H27ClN4O2/c1-17(28-25(32)20-7-6-18-4-2-3-5-19(18)14-20)16-30-12-10-22(11-13-30)31-24-9-8-21(27)15-23(24)29-26(31)33/h2-9,14-15,17,22H,10-13,16H2,1H3,(H,28,32)(H,29,33)/t17-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of PLD1 in human calu1 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM154517 (ML299 (5)) Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1cccc(F)c1)NC(=O)c1ccc(Br)cc1 Show InChI InChI=1S/C23H26BrFN4O2/c1-16(27-21(30)17-5-7-18(24)8-6-17)14-28-11-9-23(10-12-28)22(31)26-15-29(23)20-4-2-3-19(25)13-20/h2-8,13,16H,9-12,14-15H2,1H3,(H,26,31)(H,27,30)/t16-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University					Assay Description Cells were seeded into 12-well tissue culture plates to reach 90% confluence at the time of assay. All cell types, aside from the HEK293-gfpPLD2 cell...				ACS Chem Biol 10: 421-32 (2015) Article DOI: 10.1021/cb500828m BindingDB Entry DOI: 10.7270/Q2H70DK8
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phospholipase D2 (Homo sapiens (Human))	BDBM87120 (CHEMBL1254577 | N-[2-[1-(3-fluorophenyl)-4-keto-1,...) Show SMILES Fc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C26H27FN4O2/c27-22-6-3-7-23(17-22)31-18-29-25(33)26(31)10-13-30(14-11-26)15-12-28-24(32)21-9-8-19-4-1-2-5-20(19)16-21/h1-9,16-17H,10-15,18H2,(H,28,32)(H,29,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PLD2A in human HEK293 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM87245 (CHEMBL492797 | ML272 | N-(2-(4-(2-Oxo-2,3-dihydro-...) Show SMILES O=C(NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C25H26N4O2/c30-24(20-10-9-18-5-1-2-6-19(18)17-20)26-13-16-28-14-11-21(12-15-28)29-23-8-4-3-7-22(23)27-25(29)31/h1-10,17,21H,11-16H2,(H,26,30)(H,27,31)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University					Assay Description Cells were seeded into 12-well tissue culture plates to reach 90% confluence at the time of assay. All cell types, aside from the HEK293-gfpPLD2 cell...				ACS Chem Biol 10: 421-32 (2015) Article DOI: 10.1021/cb500828m BindingDB Entry DOI: 10.7270/Q2H70DK8
					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM50278141 ((S)-N-(1-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec...) Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccccc1)NC(=O)c1ccc2ccccc2c1 |r| Show InChI InChI=1S/C27H30N4O2/c1-20(29-25(32)23-12-11-21-7-5-6-8-22(21)17-23)18-30-15-13-27(14-16-30)26(33)28-19-31(27)24-9-3-2-4-10-24/h2-12,17,20H,13-16,18-19H2,1H3,(H,28,33)(H,29,32)/t20-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of PLD1 in human calu1 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM87177 (5-fluoranyl-N-[2-[1-(3-fluorophenyl)-4-oxidanylide...) Show SMILES Fc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2cc3cc(F)ccc3[nH]2)CC1 Show InChI InChI=1S/C24H25F2N5O2/c25-17-2-1-3-19(14-17)31-15-28-23(33)24(31)6-9-30(10-7-24)11-8-27-22(32)21-13-16-12-18(26)4-5-20(16)29-21/h1-5,12-14,29H,6-11,15H2,(H,27,32)(H,28,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PLD2A in human HEK293 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM87166 (5-fluoranyl-N-[2-[1-(4-fluorophenyl)-4-oxidanylide...) Show SMILES Fc1ccc(cc1)N1CNC(=O)C11CCN(CCNC(=O)c2cc3cc(F)ccc3[nH]2)CC1 Show InChI InChI=1S/C24H25F2N5O2/c25-17-1-4-19(5-2-17)31-15-28-23(33)24(31)7-10-30(11-8-24)12-9-27-22(32)21-14-16-13-18(26)3-6-20(16)29-21/h1-6,13-14,29H,7-12,15H2,(H,27,32)(H,28,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PLD2A in human HEK293 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM87164 (CHEMBL1253820 | N-[2-[1-(4-fluorophenyl)-4-keto-1,...) Show SMILES Fc1ccc(cc1)N1CNC(=O)C11CCN(CCNC(=O)c2cnc3ccccc3c2)CC1 Show InChI InChI=1S/C25H26FN5O2/c26-20-5-7-21(8-6-20)31-17-29-24(33)25(31)9-12-30(13-10-25)14-11-27-23(32)19-15-18-3-1-2-4-22(18)28-16-19/h1-8,15-16H,9-14,17H2,(H,27,32)(H,29,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PLD2A in human HEK293 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM87142 (CHEMBL1254081 | N-[2-[1-(4-chlorophenyl)-4-keto-1,...) Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)NCCN1CCC2(CC1)N(CNC2=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C24H25ClFN5O2/c25-17-1-4-19(5-2-17)31-15-28-23(33)24(31)7-10-30(11-8-24)12-9-27-22(32)21-14-16-13-18(26)3-6-20(16)29-21/h1-6,13-14,29H,7-12,15H2,(H,27,32)(H,28,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PLD2A in human HEK293 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM50326960 ((S)-N-(1-(1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspi...) Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1cccc(F)c1)NC(=O)c1ccc2ccccc2c1 |r| Show InChI InChI=1S/C27H29FN4O2/c1-19(30-25(33)22-10-9-20-5-2-3-6-21(20)15-22)17-31-13-11-27(12-14-31)26(34)29-18-32(27)24-8-4-7-23(28)16-24/h2-10,15-16,19H,11-14,17-18H2,1H3,(H,29,34)(H,30,33)/t19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PLD2A in human HEK293 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM87184 (CHEMBL1254653 | N-[2-[1-(3-fluorophenyl)-4-keto-1,...) Show SMILES Fc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2cnc3ccccc3c2)CC1 Show InChI InChI=1S/C25H26FN5O2/c26-20-5-3-6-21(15-20)31-17-29-24(33)25(31)8-11-30(12-9-25)13-10-27-23(32)19-14-18-4-1-2-7-22(18)28-16-19/h1-7,14-16H,8-13,17H2,(H,27,32)(H,29,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PLD2A in human HEK293 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM87160 (CHEMBL1254996 | N-[2-[1-(3,4-difluorophenyl)-4-ket...) Show SMILES Fc1ccc(cc1F)N1CNC(=O)C11CCN(CCNC(=O)c2cnc3ccccc3c2)CC1 Show InChI InChI=1S/C25H25F2N5O2/c26-20-6-5-19(14-21(20)27)32-16-30-24(34)25(32)7-10-31(11-8-25)12-9-28-23(33)18-13-17-3-1-2-4-22(17)29-15-18/h1-6,13-15H,7-12,16H2,(H,28,33)(H,30,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PLD2A in human HEK293 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM87147 (CHEMBL1254823 | N-[2-[1-(3-chlorophenyl)-4-keto-1,...) Show SMILES Fc1ccc(cc1)C(=O)NCCN1CCC2(CC1)N(CNC2=O)c1cccc(Cl)c1 Show InChI InChI=1S/C22H24ClFN4O2/c23-17-2-1-3-19(14-17)28-15-26-21(30)22(28)8-11-27(12-9-22)13-10-25-20(29)16-4-6-18(24)7-5-16/h1-7,14H,8-13,15H2,(H,25,29)(H,26,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PLD2A in human HEK293 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM87148 (CHEMBL1254908 | N-[2-[1-(3-chlorophenyl)-4-keto-1,...) Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)NCCN1CCC2(CC1)N(CNC2=O)c1cccc(Cl)c1 Show InChI InChI=1S/C24H25ClFN5O2/c25-17-2-1-3-19(14-17)31-15-28-23(33)24(31)6-9-30(10-7-24)11-8-27-22(32)21-13-16-12-18(26)4-5-20(16)29-21/h1-5,12-14,29H,6-11,15H2,(H,27,32)(H,28,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PLD2A in human HEK293 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM87163 (CHEMBL1255082 | N-[2-[1-(4-fluorophenyl)-4-keto-1,...) Show SMILES Fc1ccc(cc1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C26H27FN4O2/c27-22-7-9-23(10-8-22)31-18-29-25(33)26(31)11-14-30(15-12-26)16-13-28-24(32)21-6-5-19-3-1-2-4-20(19)17-21/h1-10,17H,11-16,18H2,(H,28,32)(H,29,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PLD2A in human HEK293 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM87137 (CHEMBL1255081 | N-[2-[1-(3,4-difluorophenyl)-4-ket...) Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)NCCN1CCC2(CC1)N(CNC2=O)c1ccc(F)c(F)c1 Show InChI InChI=1S/C24H24F3N5O2/c25-16-1-4-20-15(11-16)12-21(30-20)22(33)28-7-10-31-8-5-24(6-9-31)23(34)29-14-32(24)17-2-3-18(26)19(27)13-17/h1-4,11-13,30H,5-10,14H2,(H,28,33)(H,29,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PLD2A in human HEK293 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM87170 (CHEMBL1254176 | N-[2-[1-(4-bromophenyl)-4-keto-1,3...) Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)NCCN1CCC2(CC1)N(CNC2=O)c1ccc(Br)cc1 Show InChI InChI=1S/C24H25BrFN5O2/c25-17-1-4-19(5-2-17)31-15-28-23(33)24(31)7-10-30(11-8-24)12-9-27-22(32)21-14-16-13-18(26)3-6-20(16)29-21/h1-6,13-14,29H,7-12,15H2,(H,27,32)(H,28,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PLD2A in human HEK293 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM50278167 (CHEMBL511475 | N-(2-(4-Oxo-1-phenyl-1,3,8-triazasp...) Show SMILES O=C(NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc2ccccc2c1 Show InChI InChI=1S/C26H28N4O2/c31-24(22-11-10-20-6-4-5-7-21(20)18-22)27-14-17-29-15-12-26(13-16-29)25(32)28-19-30(26)23-8-2-1-3-9-23/h1-11,18H,12-17,19H2,(H,27,31)(H,28,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PLD2A in human HEK293 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM87135 (CHEMBL1254909 | N-[2-[1-(3,4-difluorophenyl)-4-ket...) Show SMILES Fc1ccc(cc1F)N1CNC(=O)C11CCN(CCNC(=O)c2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C26H26F2N4O2/c27-22-8-7-21(16-23(22)28)32-17-30-25(34)26(32)9-12-31(13-10-26)14-11-29-24(33)20-6-5-18-3-1-2-4-19(18)15-20/h1-8,15-16H,9-14,17H2,(H,29,33)(H,30,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PLD2A in human HEK293 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM50278141 ((S)-N-(1-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec...) Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccccc1)NC(=O)c1ccc2ccccc2c1 |r| Show InChI InChI=1S/C27H30N4O2/c1-20(29-25(32)23-12-11-21-7-5-6-8-22(21)17-23)18-30-15-13-27(14-16-30)26(33)28-19-31(27)24-9-3-2-4-10-24/h2-12,17,20H,13-16,18-19H2,1H3,(H,28,33)(H,29,32)/t20-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PLD2A in human HEK293 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM87146 (CHEMBL1254822 | N-[2-[1-(3-chlorophenyl)-4-keto-1,...) Show SMILES Clc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2cnc3ccccc3c2)CC1 Show InChI InChI=1S/C25H26ClN5O2/c26-20-5-3-6-21(15-20)31-17-29-24(33)25(31)8-11-30(12-9-25)13-10-27-23(32)19-14-18-4-1-2-7-22(18)28-16-19/h1-7,14-16H,8-13,17H2,(H,27,32)(H,29,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	165	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PLD2A in human HEK293 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM87139 (CHEMBL1253988 | N-[2-[1-(4-chlorophenyl)-4-keto-1,...) Show SMILES Clc1ccc(cc1)N1CNC(=O)C11CCN(CCNC(=O)c2cnc3ccccc3c2)CC1 Show InChI InChI=1S/C25H26ClN5O2/c26-20-5-7-21(8-6-20)31-17-29-24(33)25(31)9-12-30(13-10-25)14-11-27-23(32)19-15-18-3-1-2-4-22(18)28-16-19/h1-8,15-16H,9-14,17H2,(H,27,32)(H,29,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PLD2A in human HEK293 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM87177 (5-fluoranyl-N-[2-[1-(3-fluorophenyl)-4-oxidanylide...) Show SMILES Fc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2cc3cc(F)ccc3[nH]2)CC1 Show InChI InChI=1S/C24H25F2N5O2/c25-17-2-1-3-19(14-17)31-15-28-23(33)24(31)6-9-30(10-7-24)11-8-27-22(32)21-13-16-12-18(26)4-5-20(16)29-21/h1-5,12-14,29H,6-11,15H2,(H,27,32)(H,28,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of PLD1 in human calu1 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM87148 (CHEMBL1254908 | N-[2-[1-(3-chlorophenyl)-4-keto-1,...) Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)NCCN1CCC2(CC1)N(CNC2=O)c1cccc(Cl)c1 Show InChI InChI=1S/C24H25ClFN5O2/c25-17-2-1-3-19(14-17)31-15-28-23(33)24(31)6-9-30(10-7-24)11-8-27-22(32)21-13-16-12-18(26)4-5-20(16)29-21/h1-5,12-14,29H,6-11,15H2,(H,27,32)(H,28,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of PLD1 in human calu1 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM87166 (5-fluoranyl-N-[2-[1-(4-fluorophenyl)-4-oxidanylide...) Show SMILES Fc1ccc(cc1)N1CNC(=O)C11CCN(CCNC(=O)c2cc3cc(F)ccc3[nH]2)CC1 Show InChI InChI=1S/C24H25F2N5O2/c25-17-1-4-19(5-2-17)31-15-28-23(33)24(31)7-10-30(11-8-24)12-9-27-22(32)21-14-16-13-18(26)3-6-20(16)29-21/h1-6,13-14,29H,7-12,15H2,(H,27,32)(H,28,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of PLD1 in human calu1 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM87145 (CHEMBL1254737 | N-[2-[1-(3-chlorophenyl)-4-keto-1,...) Show SMILES Clc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C26H27ClN4O2/c27-22-6-3-7-23(17-22)31-18-29-25(33)26(31)10-13-30(14-11-26)15-12-28-24(32)21-9-8-19-4-1-2-5-20(19)16-21/h1-9,16-17H,10-15,18H2,(H,28,32)(H,29,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PLD2A in human HEK293 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM87142 (CHEMBL1254081 | N-[2-[1-(4-chlorophenyl)-4-keto-1,...) Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)NCCN1CCC2(CC1)N(CNC2=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C24H25ClFN5O2/c25-17-1-4-19(5-2-17)31-15-28-23(33)24(31)7-10-30(11-8-24)12-9-27-22(32)21-14-16-13-18(26)3-6-20(16)29-21/h1-6,13-14,29H,7-12,15H2,(H,27,32)(H,28,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	335	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of PLD1 in human calu1 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM87167 (CHEMBL1254082 | N-[2-[1-(4-bromophenyl)-4-keto-1,3...) Show SMILES Brc1ccc(cc1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C26H27BrN4O2/c27-22-7-9-23(10-8-22)31-18-29-25(33)26(31)11-14-30(15-12-26)16-13-28-24(32)21-6-5-19-3-1-2-4-20(19)17-21/h1-10,17H,11-16,18H2,(H,28,32)(H,29,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PLD2A in human HEK293 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM87123 (3,4-bis(fluoranyl)-N-[2-[1-(3-fluorophenyl)-4-oxid...) Show SMILES Fc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc(F)c(F)c2)CC1 Show InChI InChI=1S/C22H23F3N4O2/c23-16-2-1-3-17(13-16)29-14-27-21(31)22(29)6-9-28(10-7-22)11-8-26-20(30)15-4-5-18(24)19(25)12-15/h1-5,12-13H,6-11,14H2,(H,26,30)(H,27,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	355	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University					Assay Description Cells were seeded into 12-well tissue culture plates to reach 90% confluence at the time of assay. All cell types, aside from the HEK293-gfpPLD2 cell...				ACS Chem Biol 10: 421-32 (2015) Article DOI: 10.1021/cb500828m BindingDB Entry DOI: 10.7270/Q2H70DK8
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM87168 (CHEMBL1254576 | N-[2-[1-(4-bromophenyl)-4-keto-1,3...) Show SMILES Brc1ccc(cc1)N1CNC(=O)C11CCN(CCNC(=O)c2cnc3ccccc3c2)CC1 Show InChI InChI=1S/C25H26BrN5O2/c26-20-5-7-21(8-6-20)31-17-29-24(33)25(31)9-12-30(13-10-25)14-11-27-23(32)19-15-18-3-1-2-4-22(18)28-16-19/h1-8,15-16H,9-14,17H2,(H,27,32)(H,29,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PLD2A in human HEK293 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM154518 (ML395 (6)) Show SMILES O=C(NCCN1CCC2(CC1)N(Cc1cccnc1)CNC2=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C26H29N5O2/c32-24(23-8-7-21-5-1-2-6-22(21)16-23)28-12-15-30-13-9-26(10-14-30)25(33)29-19-31(26)18-20-4-3-11-27-17-20/h1-8,11,16-17H,9-10,12-15,18-19H2,(H,28,32)(H,29,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University					Assay Description Cells were seeded into 12-well tissue culture plates to reach 90% confluence at the time of assay. All cell types, aside from the HEK293-gfpPLD2 cell...				ACS Chem Biol 10: 421-32 (2015) Article DOI: 10.1021/cb500828m BindingDB Entry DOI: 10.7270/Q2H70DK8
					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM87137 (CHEMBL1255081 | N-[2-[1-(3,4-difluorophenyl)-4-ket...) Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)NCCN1CCC2(CC1)N(CNC2=O)c1ccc(F)c(F)c1 Show InChI InChI=1S/C24H24F3N5O2/c25-16-1-4-20-15(11-16)12-21(30-20)22(33)28-7-10-31-8-5-24(6-9-31)23(34)29-14-32(24)17-2-3-18(26)19(27)13-17/h1-4,11-13,30H,5-10,14H2,(H,28,33)(H,29,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of PLD1 in human calu1 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM87165 (4-fluoranyl-N-[2-[1-(4-fluorophenyl)-4-oxidanylide...) Show SMILES Fc1ccc(cc1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc(F)cc2)CC1 Show InChI InChI=1S/C22H24F2N4O2/c23-17-3-1-16(2-4-17)20(29)25-11-14-27-12-9-22(10-13-27)21(30)26-15-28(22)19-7-5-18(24)6-8-19/h1-8H,9-15H2,(H,25,29)(H,26,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	610	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PLD2A in human HEK293 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM87138 (CHEMBL1253901 | N-[2-[1-(4-chlorophenyl)-4-keto-1,...) Show SMILES Clc1ccc(cc1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C26H27ClN4O2/c27-22-7-9-23(10-8-22)31-18-29-25(33)26(31)11-14-30(15-12-26)16-13-28-24(32)21-6-5-19-3-1-2-4-20(19)17-21/h1-10,17H,11-16,18H2,(H,28,32)(H,29,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	655	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PLD2A in human HEK293 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM87161 (CHEMBL1254997 | N-[2-[1-(3,4-difluorophenyl)-4-ket...) Show SMILES Fc1ccc(cc1)C(=O)NCCN1CCC2(CC1)N(CNC2=O)c1ccc(F)c(F)c1 Show InChI InChI=1S/C22H23F3N4O2/c23-16-3-1-15(2-4-16)20(30)26-9-12-28-10-7-22(8-11-28)21(31)27-14-29(22)17-5-6-18(24)19(25)13-17/h1-6,13H,7-12,14H2,(H,26,30)(H,27,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	660	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PLD2A in human HEK293 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM87146 (CHEMBL1254822 | N-[2-[1-(3-chlorophenyl)-4-keto-1,...) Show SMILES Clc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2cnc3ccccc3c2)CC1 Show InChI InChI=1S/C25H26ClN5O2/c26-20-5-3-6-21(15-20)31-17-29-24(33)25(31)8-11-30(12-9-25)13-10-27-23(32)19-14-18-4-1-2-7-22(18)28-16-19/h1-7,14-16H,8-13,17H2,(H,27,32)(H,29,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	870	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of PLD1 in human calu1 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM50278167 (CHEMBL511475 | N-(2-(4-Oxo-1-phenyl-1,3,8-triazasp...) Show SMILES O=C(NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc2ccccc2c1 Show InChI InChI=1S/C26H28N4O2/c31-24(22-11-10-20-6-4-5-7-21(20)18-22)27-14-17-29-15-12-26(13-16-29)25(32)28-19-30(26)23-8-2-1-3-9-23/h1-11,18H,12-17,19H2,(H,27,31)(H,28,32)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of PLD1 in human calu1 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM87145 (CHEMBL1254737 | N-[2-[1-(3-chlorophenyl)-4-keto-1,...) Show SMILES Clc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C26H27ClN4O2/c27-22-6-3-7-23(17-22)31-18-29-25(33)26(31)10-13-30(14-11-26)15-12-28-24(32)21-9-8-19-4-1-2-5-20(19)16-21/h1-9,16-17H,10-15,18H2,(H,28,32)(H,29,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of PLD1 in human calu1 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM87120 (CHEMBL1254577 | N-[2-[1-(3-fluorophenyl)-4-keto-1,...) Show SMILES Fc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C26H27FN4O2/c27-22-6-3-7-23(17-22)31-18-29-25(33)26(31)10-13-30(14-11-26)15-12-28-24(32)21-9-8-19-4-1-2-5-20(19)16-21/h1-9,16-17H,10-15,18H2,(H,28,32)(H,29,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University					Assay Description Cells were seeded into 12-well tissue culture plates to reach 90% confluence at the time of assay. All cell types, aside from the HEK293-gfpPLD2 cell...				ACS Chem Biol 10: 421-32 (2015) Article DOI: 10.1021/cb500828m BindingDB Entry DOI: 10.7270/Q2H70DK8
					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM87120 (CHEMBL1254577 | N-[2-[1-(3-fluorophenyl)-4-keto-1,...) Show SMILES Fc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C26H27FN4O2/c27-22-6-3-7-23(17-22)31-18-29-25(33)26(31)10-13-30(14-11-26)15-12-28-24(32)21-9-8-19-4-1-2-5-20(19)16-21/h1-9,16-17H,10-15,18H2,(H,28,32)(H,29,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of PLD1 in human calu1 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM87163 (CHEMBL1255082 | N-[2-[1-(4-fluorophenyl)-4-keto-1,...) Show SMILES Fc1ccc(cc1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C26H27FN4O2/c27-22-7-9-23(10-8-22)31-18-29-25(33)26(31)11-14-30(15-12-26)16-13-28-24(32)21-6-5-19-3-1-2-4-20(19)17-21/h1-10,17H,11-16,18H2,(H,28,32)(H,29,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of PLD1 in human calu1 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM50258182 ((S)-N-(1-(4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzo[d...) Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O)NC(=O)c1ccc2ccccc2c1 |r| Show InChI InChI=1S/C26H27ClN4O2/c1-17(28-25(32)20-7-6-18-4-2-3-5-19(18)14-20)16-30-12-10-22(11-13-30)31-24-9-8-21(27)15-23(24)29-26(31)33/h2-9,14-15,17,22H,10-13,16H2,1H3,(H,28,32)(H,29,33)/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PLD2A in human HEK293 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D2 (Homo sapiens (Human))	BDBM75441 (1-[2-[4-[2-(3-methoxyphenyl)-1-benzothiophen-3-yl]...) Show SMILES COc1cccc(c1)-c1sc2ccccc2c1-c1ccc(OCCN2CCCC2)cc1 Show InChI InChI=1S/C27H27NO2S/c1-29-23-8-6-7-21(19-23)27-26(24-9-2-3-10-25(24)31-27)20-11-13-22(14-12-20)30-18-17-28-15-4-5-16-28/h2-3,6-14,19H,4-5,15-18H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	7.5	n/a
Vanderbilt University					Assay Description Briefly, PLD activity was measured as the release of free [3H]-choline from [choline-methyl-3H] dipalmitoylphosphatidylcholine ([3H]-DPPC). 3−5...				ACS Chem Biol 10: 421-32 (2015) Article DOI: 10.1021/cb500828m BindingDB Entry DOI: 10.7270/Q2H70DK8
					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM87164 (CHEMBL1253820 | N-[2-[1-(4-fluorophenyl)-4-keto-1,...) Show SMILES Fc1ccc(cc1)N1CNC(=O)C11CCN(CCNC(=O)c2cnc3ccccc3c2)CC1 Show InChI InChI=1S/C25H26FN5O2/c26-20-5-7-21(8-6-20)31-17-29-24(33)25(31)9-12-30(13-10-25)14-11-27-23(32)19-15-18-3-1-2-4-22(18)28-16-19/h1-8,15-16H,9-14,17H2,(H,27,32)(H,29,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of PLD1 in human calu1 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM87160 (CHEMBL1254996 | N-[2-[1-(3,4-difluorophenyl)-4-ket...) Show SMILES Fc1ccc(cc1F)N1CNC(=O)C11CCN(CCNC(=O)c2cnc3ccccc3c2)CC1 Show InChI InChI=1S/C25H25F2N5O2/c26-20-6-5-19(14-21(20)27)32-16-30-24(34)25(32)7-10-31(11-8-25)12-9-28-23(33)18-13-17-3-1-2-4-22(17)29-15-18/h1-6,13-15H,7-12,16H2,(H,28,33)(H,30,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.06E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of PLD1 in human calu1 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair
Phospholipase (Pseudomonas aeruginosa (g-Proteobacteria))	BDBM154526 (22B1 (17i)) Show SMILES Oc1ccc(cc1)-c1c(sc2ccccc12)-c1cccc(O)c1 Show InChI InChI=1S/C20H14O2S/c21-15-10-8-13(9-11-15)19-17-6-1-2-7-18(17)23-20(19)14-4-3-5-16(22)12-14/h1-12,21-22H	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	7.5	n/a
Vanderbilt University					Assay Description In a 96-black well plate, in a final reaction volume of 200 μL, the following components were combined on ice to yield final concentrations of 5...				ACS Chem Biol 10: 421-32 (2015) Article DOI: 10.1021/cb500828m BindingDB Entry DOI: 10.7270/Q2H70DK8
					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM87138 (CHEMBL1253901 | N-[2-[1-(4-chlorophenyl)-4-keto-1,...) Show SMILES Clc1ccc(cc1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C26H27ClN4O2/c27-22-7-9-23(10-8-22)31-18-29-25(33)26(31)11-14-30(15-12-26)16-13-28-24(32)21-6-5-19-3-1-2-4-20(19)17-21/h1-10,17H,11-16,18H2,(H,28,32)(H,29,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.27E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of PLD1 in human calu1 cells				J Med Chem 53: 6706-19 (2010) Article DOI: 10.1021/jm100814g BindingDB Entry DOI: 10.7270/Q2XW4K1Z
					More data for this Ligand-Target Pair

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