Reaction Details |
| Report a problem with these data |
Target | Replicase polyprotein 1ab [1541-1855] |
---|
Ligand | BDBM154575 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Surface Plasmon Resonance |
---|
pH | 7.4±n/a |
---|
Kd | 3.14e+4±n/a nM |
---|
Comments | extracted |
---|
Citation | Lee, H; Lei, H; Santarsiero, BD; Gatuz, JL; Cao, S; Rice, AJ; Patel, K; Szypulinski, MZ; Ojeda, I; Ghosh, AK; Johnson, ME Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV. ACS Chem Biol10:1456-65 (2015) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Replicase polyprotein 1ab [1541-1855] |
---|
Name: | Replicase polyprotein 1ab [1541-1855] |
Synonyms: | R1AB_SARS | SARS Coronavirus Coronavirus Papain-Like Protease | SARS-CoV PLpro | SARS-CoV papain-like protease (SARS-PLpro) | rep |
Type: | Hydrolase |
Mol. Mass.: | 35352.30 |
Organism: | Human SARS coronavirus (SARS-CoV) |
Description: | The SARS-CoV PLpro enzyme (residues 1541 -1855) was expressed and purified from E. coli. |
Residue: | 315 |
Sequence: | EVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPS
DDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLAL
QQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLES
AKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESS
FVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPV
TDVFYKETSYTTTIK
|
|
|
BDBM154575 |
---|
n/a |
---|
Name | BDBM154575 |
Synonyms: | 3-chloro-N-[5-(7-ethoxy-1-benzofuran-2-yl)-1,3,4-oxadiazol-2-yl]-1-benzothiophene-2-carboxamide (3) |
Type | Small organic molecule |
Emp. Form. | C21H14ClN3O4S |
Mol. Mass. | 439.872 |
SMILES | CCOc1cccc2cc(oc12)-c1nnc(NC(=O)c2sc3ccccc3c2Cl)o1 |
Structure |
|