| Reaction Details |
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 | Report a problem with these data |
| Target | AMP deaminase 1 |
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| Ligand | BDBM154582 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | AMPD Enzymatic Activity Assay |
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| pH | 7.4±n/a |
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| IC50 | 9.2e+3± 2.0e+3 nM |
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| Comments | extracted |
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| Citation |  Admyre, T; Amrot-Fors, L; Andersson, M; Bauer, M; Bjursell, M; Drmota, T; Hallen, S; Hartleib-Geschwindner, J; Lindmark, B; Liu, J; Löfgren, L; Rohman, M; Selmi, N; Wallenius, K Inhibition of AMP deaminase activity does not improve glucose control in rodent models of insulin resistance or diabetes. Chem Biol21:1486-96 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| AMP deaminase 1 |
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| Name: | AMP deaminase 1 |
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| Synonyms: | AMP deaminase 1 (hAMPD1) | AMP deaminase isoform M | AMPD1 | AMPD1_HUMAN | Myoadenylate deaminase |
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| Type: | Protein |
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| Mol. Mass.: | 90225.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 780 |
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| Sequence: | MNVRIFYSVSQSPHSLLSLLFYCAILESRISATMPLFKLPAEEKQIDDAMRNFAEKVFAS
EVKDEGGRQEISPFDVDEICPISHHEMQAHIFHLETLSTSTEARRKKRFQGRKTVNLSIP
LSETSSTKLSHIDEYISSSPTYQTVPDFQRVQITGDYASGVTVEDFEIVCKGLYRALCIR
EKYMQKSFQRFPKTPSKYLRNIDGEAWVANESFYPVFTPPVKKGEDPFRTDNLPENLGYH
LKMKDGVVYVYPNEAAVSKDEPKPLPYPNLDTFLDDMNFLLALIAQGPVKTYTHRRLKFL
SSKFQVHQMLNEMDELKELKNNPHRDFYNCRKVDTHIHAAACMNQKHLLRFIKKSYQIDA
DRVVYSTKEKNLTLKELFAKLKMHPYDLTVDSLDVHAGRQTFQRFDKFNDKYNPVGASEL
RDLYLKTDNYINGEYFATIIKEVGADLVEAKYQHAEPRLSIYGRSPDEWSKLSSWFVCNR
IHCPNMTWMIQVPRIYDVFRSKNFLPHFGKMLENIFMPVFEATINPQADPELSVFLKHIT
GFDSVDDESKHSGHMFSSKSPKPQEWTLEKNPSYTYYAYYMYANIMVLNSLRKERGMNTF
LFRPHCGEAGALTHLMTAFMIADDISHGLNLKKSPVLQYLFFLAQIPIAMSPLSNNSLFL
EYAKNPFLDFLQKGLMISLSTDDPMQFHFTKEPLMEEYAIAAQVFKLSTCDMCEVARNSV
LQCGISHEEKVKFLGDNYLEEGPAGNDIRRTNVAQIRMAYRYETWCYELNLIAEGLKSTE
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| BDBM154582 |
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| n/a |
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| Name | BDBM154582 |
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| Synonyms: | 6-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methyl)phenyl]pyridine-3-carboxylic acid (Compound 2) |
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| Type | Small organic molecule |
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| Emp. Form. | C24H21N3O2 |
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| Mol. Mass. | 383.4424 |
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| SMILES | C[C@@H](NCc1ccc(cc1)-c1ccc(cn1)C(O)=O)c1cccc2ccncc12 |r| |
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| Structure | 
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