| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 3 |
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| Ligand | BDBM154600 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Temperature Dependence Fluorescence Assay (TdF) |
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| Kd | 0.6±n/a nM |
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| Citation |  Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Heterocyclic compounds as ERK inhibitors US Patent US8999957 Publication Date 4/7/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 3 |
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| Name: | Mitogen-activated protein kinase 3 |
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| Synonyms: | Erk1 | Extracellular signal-regulated kinase 1 (ERK1) | MK03_MOUSE | Mapk3 | Prkm3 |
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| Type: | Protein |
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| Mol. Mass.: | 43066.49 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | Q63844 |
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| Residue: | 380 |
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| Sequence: | MAAAAAAPGGGGGEPRGTAGVVPVVPGEVEVVKGQPFDVGPRYTQLQYIGEGAYGMVSSA
YDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPTLEAMRDVY
IVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCD
LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML
SNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKS
DSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFDMELDDLPKER
LKELIFQETARFQPGAPEGP
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| BDBM154600 |
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| n/a |
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| Name | BDBM154600 |
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| Synonyms: | US8999957, Column 153, Compound 5 | US8999957, Table 1, Compound 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24FN5O |
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| Mol. Mass. | 429.4894 |
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| SMILES | Fc1ccccc1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 |r| |
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| Structure | 
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