Reaction Details |
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Target | Tyrosine-protein kinase BTK [393-659] |
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Ligand | BDBM287204 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) |
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pH | 6.5±n/a |
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Temperature | 298.15±n/a K |
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IC50 | <100±n/a nM |
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Comments | extracted |
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Citation | Bonafoux, D; Davis, HM; Frank, KE; Friedman, MM; Herold, JM; Hoemann, MZ; Huntley, R; Osuma, A; Sheppard, G; Somal, GK; Van Camp, J; Van Epps, SA; Vasudevan, A; Wallace, GA; Wang, L; Wang, L; Wang, Z; Wilson, NS; Xu, X Primary carboxamides as BTK inhibitors US Patent US9567339 Publication Date 2/14/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase BTK [393-659] |
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Name: | Tyrosine-protein kinase BTK [393-659] |
Synonyms: | AGMX1 | ATK | BPK | BTK | BTK_HUMAN | Tyrosine-protein kinase BTK |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 31165.48 |
Organism: | Homo sapiens (Human) |
Description: | aa 393-659 |
Residue: | 267 |
Sequence: | GSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNL
SHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYL
ESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYS
KFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYS
CWHEKADERPTFKILLSNILDVMDEES
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BDBM287204 |
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n/a |
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Name | BDBM287204 |
Synonyms: | US9567339, Example A.3.8 |
Type | Small organic molecule |
Emp. Form. | C34H33N5O3 |
Mol. Mass. | 559.6575 |
SMILES | CC(=O)N1CCC(=CC1)c1cc2c(ccc(C(N)=O)c2[nH]1)-c1cccc(NC(=O)c2ccc(cc2)C(C)(C)C#N)c1C |c:6| |
Structure |
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