| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase BTK [393-659] |
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| Ligand | BDBM287414 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) |
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| pH | 6.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | <100±n/a nM |
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| Comments | extracted |
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| Citation |  Bonafoux, D; Davis, HM; Frank, KE; Friedman, MM; Herold, JM; Hoemann, MZ; Huntley, R; Osuma, A; Sheppard, G; Somal, GK; Van Camp, J; Van Epps, SA; Vasudevan, A; Wallace, GA; Wang, L; Wang, L; Wang, Z; Wilson, NS; Xu, X Primary carboxamides as BTK inhibitors US Patent US9567339 Publication Date 2/14/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Tyrosine-protein kinase BTK [393-659] |
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| Name: | Tyrosine-protein kinase BTK [393-659] |
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| Synonyms: | AGMX1 | ATK | BPK | BTK | BTK_HUMAN | Tyrosine-protein kinase BTK |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 31165.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 393-659 |
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| Residue: | 267 |
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| Sequence: | GSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNL
SHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYL
ESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYS
KFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYS
CWHEKADERPTFKILLSNILDVMDEES
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|
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| BDBM287414 |
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| n/a |
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| Name | BDBM287414 |
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| Synonyms: | US9567339, Example E.9.13 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H30N6O3 |
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| Mol. Mass. | 474.5548 |
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| SMILES | CN(C1CN(C1)C(=O)C=C)c1ccc(C(N)=O)c2[nH]c(cc12)-c1ccc(CN2CCOCC2)cn1 |
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| Structure | 
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