| Reaction Details |
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 | Report a problem with these data |
| Target | Steroid 17-alpha-hydroxylase/17,20 lyase |
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| Ligand | BDBM158429 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 7.5±n/a |
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| IC50 | 1.1±n/a nM |
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| Comments | extracted |
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| Citation |  Bock, MG; Gaul, C; Gummadi, VR; Sengupta, S 17α-hydroxylase/C17,20-lyase inhibitors US Patent US9029399 Publication Date 5/12/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Steroid 17-alpha-hydroxylase/17,20 lyase |
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| Name: | Steroid 17-alpha-hydroxylase/17,20 lyase |
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| Synonyms: | CP17A_RAT | Cyp17 | Cyp17a1 | Cytochrome P450 17,20 lyase | Cytochrome P450 17A1 | Cytochrome P450-C17 | Steroid 17-alpha-hydroxylase/17,20 lyase |
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| Type: | Enzyme |
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| Mol. Mass.: | 57255.68 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P11715 |
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| Residue: | 507 |
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| Sequence: | MWELVGLLLLILAYFFWVKSKTPGAKLPRSLPSLPLVGSLPFLPRRGHMHVNFFKLQEKY
GPIYSLRLGTTTTVIIGHYQLAREVLIKKGKEFSGRPQMVTQSLLSDQGKGVAFADAGSS
WHLHRKLVFSTFSLFKDGQKLEKLICQEAKSLCDMMLAHDKESIDLSTPIFMSVTNIICA
ICFNISYEKNDPKLTAIKTFTEGIVDATGDRNLVDIFPWLTIFPNKGLEVIKGYAKVRNE
VLTGIFEKCREKFDSQSISSLTDILIQAKMNSDNNNSCEGRDPDVFSDRHILATVGDIFG
AGIETTTTVLKWILAFLVHNPEVKKKIQKEIDQYVGFSRTPTFNDRSHLLMLEATIREVL
RIRPVAPMLIPHKANVDSSIGEFTVPKDTHVVVNLWALHHDENEWDQPDQFMPERFLDPT
GSHLITPTQSYLPFGAGPRSCIGEALARQELFVFTALLLQRFDLDVSDDKQLPRLEGDPK
VVFLIDPFKVKITVRQAWMDAQAEVST
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| BDBM158429 |
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| n/a |
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| Name | BDBM158429 |
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| Synonyms: | US9029399, 2A | US9339501, 2A |
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| Type | Small organic molecule |
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| Emp. Form. | C17H15F3N4O |
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| Mol. Mass. | 348.3224 |
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| SMILES | FC(F)(F)c1cc(ccn1)N1CCN(C1=O)c1cnccc1C1CC1 |
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| Structure | 
|
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