Reaction Details |
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Target | Histone deacetylase 1/Nuclear receptor corepressor 2 [395-498] |
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Ligand | BDBM163621 |
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Substrate/Competitor | n/a |
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Meas. Tech. | HDAC Activity Assays |
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IC50 | 8.86e+3±n/a nM |
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Citation | Wang, Y; Stowe, RL; Pinello, CE; Tian, G; Madoux, F; Li, D; Zhao, LY; Li, JL; Wang, Y; Wang, Y; Ma, H; Hodder, P; Roush, WR; Liao, D Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. Chem Biol22:273-84 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 1/Nuclear receptor corepressor 2 [395-498] |
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Name: | Histone deacetylase 1/Nuclear receptor corepressor 2 [395-498] |
Synonyms: | HDAC1/NCOR2 |
Type: | Protein |
Mol. Mass.: | n/a |
Description: | BPS Bioscience |
Components: | This complex has 2 components. |
Component 1 |
Name: | Histone deacetylase 1 |
Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
Type: | Enzyme |
Mol. Mass.: | 55090.27 |
Organism: | Homo sapiens (Human) |
Description: | Q13547 |
Residue: | 482 |
Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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Component 2 |
Name: | Nuclear receptor corepressor 2 [395-498] |
Synonyms: | CTG26 | Deacetylase activation domain (NCOR2) | NCOR2 | NCOR2_HUMAN | Nuclear receptor corepressor 2 |
Type: | Protein |
Mol. Mass.: | 12719.17 |
Organism: | Homo sapiens (Human) |
Description: | Deacetylase activation domain of human NCOR2 (395-498aa) |
Residue: | 104 |
Sequence: | IPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLI
ASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQ
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BDBM163621 |
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n/a |
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Name | BDBM163621 |
Synonyms: | SR-3204 | US10807944, Compound RLS2-124 | US11731934, Compound RLS2-124 |
Type | Small organic molecule |
Emp. Form. | C12H15F3N2O2 |
Mol. Mass. | 276.2549 |
SMILES | CCCCNNC(=O)c1ccc(OC(F)(F)F)cc1 |
Structure |
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