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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dipeptidyl peptidase 4 [K6R,T557I] | ||
| Ligand | BDBM167941 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | DPP-IV Inhibition Activity | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 17556±0.0 nM | ||
| Comments | extracted | ||
| Citation |  Gomha, SM; Eldebss, TM; Badrey, MG; Abdulla, MM; Mayhoub, AS Novel 4-heteroaryl-antipyrines as DPP-IV inhibitors. Chem Biol Drug Des86:1292-303 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dipeptidyl peptidase 4 [K6R,T557I] | |||
| Name: | Dipeptidyl peptidase 4 [K6R,T557I] | ||
| Synonyms: | ADCP2 | CD26 | DPP4 | DPP4_HUMAN | Dipeptidyl peptidase IV (DPP-IV) | Dipeptidyl peptidase-IV (DDP-4) | Dipeptidyl peptidase-IV (DPP-IV) | ||
| Type: | Protein | ||
| Mol. Mass.: | 88325.11 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P27487[K6R,T557I] | ||
| Residue: | 766 | ||
| Sequence: |
| ||
| BDBM167941 | |||
| n/a | |||
| Name | BDBM167941 | ||
| Synonyms: | Ethyl 6-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-methyl-5-(phenylsulfonyl)nicotinate (25a) | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H25N3O5S | ||
| Mol. Mass. | 491.559 | ||
| SMILES | CCOC(=O)c1cc(c(nc1C)-c1c(C)n(C)n(-c2ccccc2)c1=O)S(=O)(=O)c1ccccc1 |(-2.71,-13.72,;-3.34,-12.32,;-2.43,-11.07,;-3.06,-9.66,;-4.59,-9.5,;-2.15,-8.42,;-2.78,-7.01,;-1.87,-5.76,;-.34,-5.93,;.28,-7.33,;-.62,-8.58,;.01,-9.99,;.56,-4.68,;.09,-3.22,;-1.38,-2.74,;1.33,-2.31,;1.33,-.77,;2.58,-3.22,;4.04,-2.74,;4.36,-1.23,;5.83,-.76,;6.97,-1.79,;6.65,-3.29,;5.19,-3.77,;2.1,-4.68,;3.01,-5.93,;-2.5,-4.36,;-1.09,-3.73,;-3.13,-2.95,;-3.91,-4.98,;-4.07,-6.52,;-5.47,-7.14,;-6.72,-6.24,;-6.56,-4.71,;-5.15,-4.08,)| | ||
| Structure | 
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