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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dipeptidyl peptidase 4 [K6R,T557I] | ||
| Ligand | BDBM167943 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | DPP-IV Inhibition Activity | ||
| Temperature | 298.15±n/a K | ||
| IC50 | >50±0.0 nM | ||
| Comments | extracted | ||
| Citation |  Gomha, SM; Eldebss, TM; Badrey, MG; Abdulla, MM; Mayhoub, AS Novel 4-heteroaryl-antipyrines as DPP-IV inhibitors. Chem Biol Drug Des86:1292-303 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dipeptidyl peptidase 4 [K6R,T557I] | |||
| Name: | Dipeptidyl peptidase 4 [K6R,T557I] | ||
| Synonyms: | ADCP2 | CD26 | DPP4 | DPP4_HUMAN | Dipeptidyl peptidase IV (DPP-IV) | Dipeptidyl peptidase-IV (DDP-4) | Dipeptidyl peptidase-IV (DPP-IV) | ||
| Type: | Protein | ||
| Mol. Mass.: | 88325.11 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P27487[K6R,T557I] | ||
| Residue: | 766 | ||
| Sequence: |
| ||
| BDBM167943 | |||
| n/a | |||
| Name | BDBM167943 | ||
| Synonyms: | 3-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1Hpyrazol-4-yl)-2-(phenylsulfonyl)benzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile (26) | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H21N5O3S | ||
| Mol. Mass. | 519.574 | ||
| SMILES | Cc1c(-c2c(C#N)c3nc4ccccc4n3cc2S(=O)(=O)c2ccccc2)c(=O)n(-c2ccccc2)n1C |(19.46,-10.69,;19.94,-9.22,;19.03,-7.97,;17.49,-7.97,;16.72,-9.31,;17.49,-10.64,;18.26,-11.98,;15.18,-9.31,;14.15,-10.45,;12.74,-9.83,;11.34,-10.45,;10.09,-9.55,;10.25,-8.02,;11.66,-7.39,;12.9,-8.3,;14.41,-7.97,;15.18,-6.64,;16.72,-6.64,;17.49,-5.31,;18.82,-6.08,;16.16,-4.54,;18.26,-3.97,;19.8,-3.97,;20.57,-2.64,;19.8,-1.31,;18.26,-1.31,;17.49,-2.64,;19.94,-6.73,;19.46,-5.26,;21.4,-7.2,;22.65,-6.3,;24.05,-6.93,;25.3,-6.02,;25.14,-4.49,;23.73,-3.86,;22.48,-4.77,;21.4,-8.74,;22.65,-9.65,)| | ||
| Structure | 
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