Reaction Details | |||
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Target | Apoptosis regulator Bcl-2 | ||
Ligand | BDBM177838 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Fluorescence Polarisation Assay | ||
pH | 7.4±n/a | ||
IC50 | 12±n/a nM | ||
Comments | extracted | ||
Citation | Le Diguarher, T; Casara, P; Starck, J; Henlin, J; Davidson, JE; Murray, JB; Graham, CJ; Chen, I; Geneste, O; Hickman, J; Depil, S; Le Tiran, A; Nyerges, M; De Nanteuil, G Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them US Patent US9120791 Publication Date 9/1/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Apoptosis regulator Bcl-2 | |||
Name: | Apoptosis regulator Bcl-2 | ||
Synonyms: | BCL2_MOUSE | Bcl-2 | Bcl2 | ||
Type: | Protein | ||
Mol. Mass.: | 26409.44 | ||
Organism: | Mus musculus (Mouse) | ||
Description: | P10417 | ||
Residue: | 236 | ||
Sequence: |
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BDBM177838 | |||
n/a | |||
Name | BDBM177838 | ||
Synonyms: | US9120791, Example 57 | ||
Type | Small organic molecule | ||
Emp. Form. | C47H44N6O5 | ||
Mol. Mass. | 772.8895 | ||
SMILES | CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc3OCOc3c2-c2cc(C(=O)N(c3ccc(O)cc3)c3ccc4n(C)ccc4c3)c3ccccn23)CC1 |wU:6.5,(9.68,5.43,;10.45,6.76,;11.98,6.6,;12.89,7.84,;12.26,9.25,;13.17,10.5,;14.7,10.34,;15.32,8.93,;16.86,8.77,;17.48,7.36,;19.01,7.2,;19.92,8.45,;19.29,9.85,;17.76,10.01,;17.14,11.42,;15.6,11.58,;14.98,12.99,;13.45,13.15,;15.88,14.24,;17.41,14.07,;18.32,15.32,;17.69,16.73,;18.46,18.06,;17.1,19.15,;15.76,18.38,;16.16,16.89,;15.26,15.64,;13.72,15.8,;12.69,14.66,;11.29,15.28,;9.95,14.51,;9.95,12.97,;8.62,15.28,;8.62,16.82,;7.29,17.59,;7.29,19.13,;8.62,19.9,;8.62,21.44,;9.95,19.13,;9.95,17.59,;7.29,14.51,;7.29,12.97,;5.95,12.2,;4.62,12.97,;3.15,12.5,;2.68,11.03,;2.25,13.74,;3.15,14.99,;4.62,14.51,;5.95,15.28,;11.45,16.82,;10.42,17.96,;10.89,19.43,;12.4,19.75,;13.43,18.6,;12.95,17.14,;10.73,9.41,;9.83,8.17,)| | ||
Structure |