| Reaction Details |
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 | Report a problem with these data |
| Target | Apoptosis regulator Bcl-2 |
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| Ligand | BDBM177885 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Polarisation Assay |
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| pH | 7.4±n/a |
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| IC50 | 9±n/a nM |
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| Comments | extracted |
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| Citation |  Le Diguarher, T; Casara, P; Starck, J; Henlin, J; Davidson, JE; Murray, JB; Graham, CJ; Chen, I; Geneste, O; Hickman, J; Depil, S; Le Tiran, A; Nyerges, M; De Nanteuil, G Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them US Patent US9120791 Publication Date 9/1/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Apoptosis regulator Bcl-2 |
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| Name: | Apoptosis regulator Bcl-2 |
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| Synonyms: | BCL2_MOUSE | Bcl-2 | Bcl2 |
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| Type: | Protein |
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| Mol. Mass.: | 26409.44 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P10417 |
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| Residue: | 236 |
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| Sequence: | MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDADAAPLGAAPTPGIFSFQPESNPMPA
VHRDMAARTSPLRPLVATAGPALSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTP
FTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNR
HLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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| BDBM177885 |
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| n/a |
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| Name | BDBM177885 |
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| Synonyms: | US9120791, Example 114 | US9603854, 114 |
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| Type | Small organic molecule |
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| Emp. Form. | C44H45FN4O5 |
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| Mol. Mass. | 728.8503 |
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| SMILES | COc1ccc(C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)c(c1)-c1cc(C(=O)N(c2ccc(O)cc2)c2ccc(C)c(F)c2)c2CCCCn12 |
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| Structure | 
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