Reaction Details |
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Target | Apoptosis regulator Bcl-2 |
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Ligand | BDBM177890 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Fluorescence Polarisation Assay |
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pH | 7.4±n/a |
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IC50 | 9±n/a nM |
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Comments | extracted |
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Citation | Le Diguarher, T; Casara, P; Starck, J; Henlin, J; Davidson, JE; Murray, JB; Graham, CJ; Chen, I; Geneste, O; Hickman, J; Depil, S; Le Tiran, A; Nyerges, M; De Nanteuil, G Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them US Patent US9120791 Publication Date 9/1/2015 |
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More Info.: | Get all data from this article, Assay Method |
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Apoptosis regulator Bcl-2 |
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Name: | Apoptosis regulator Bcl-2 |
Synonyms: | BCL2_MOUSE | Bcl-2 | Bcl2 |
Type: | Protein |
Mol. Mass.: | 26409.44 |
Organism: | Mus musculus (Mouse) |
Description: | P10417 |
Residue: | 236 |
Sequence: | MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDADAAPLGAAPTPGIFSFQPESNPMPA
VHRDMAARTSPLRPLVATAGPALSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTP
FTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNR
HLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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BDBM177890 |
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n/a |
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Name | BDBM177890 |
Synonyms: | US9120791, Example 119 | US9603854, 119 |
Type | Small organic molecule |
Emp. Form. | C43H40ClN5O4 |
Mol. Mass. | 726.262 |
SMILES | Oc1ccc(cc1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1cccc(c1)C#N |
Structure |
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