Reaction Details |
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Target | o-succinylbenzoate synthase |
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Ligand | BDBM181040 |
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Substrate/Competitor | n/a |
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Meas. Tech. | MenE-MenB Coupled Assay |
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pH | 7.4±n/a |
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IC50 | 2.2e+3± 4e+2 nM |
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Comments | extracted |
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Citation | Matarlo, JS; Evans, CE; Sharma, I; Lavaud, LJ; Ngo, SC; Shek, R; Rajashankar, KR; French, JB; Tan, DS; Tonge, PJ Mechanism of MenE inhibition by acyl-adenylate analogues and discovery of novel antibacterial agents. Biochemistry54:6514-24 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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o-succinylbenzoate synthase |
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Name: | o-succinylbenzoate synthase |
Synonyms: | MENC_ECOLI | menC | o-Succinylbenzoyl-CoA synthase (MenE) |
Type: | Protein |
Mol. Mass.: | 35465.11 |
Organism: | Escherichia coli K-12 (Enterobacteria) |
Description: | n/a |
Residue: | 320 |
Sequence: | MRSAQVYRWQIPMDAGVVLRDRRLKTRDGLYVCLREGEREGWGEISPLPGFSQETWEEAQ
SVLLAWVNNWLAGDCELPQMPSVAFGVSCALAELTDTLPQAANYRAAPLCNGDPDDLILK
LADMPGEKVAKVKVGLYEAVRDGMVVNLLLEAIPDLHLRLDANRAWTPLKGQQFAKYVNP
DYRDRIAFLEEPCKTRDDSRAFARETGIAIAWDESLREPDFAFVAEEGVRAVVIKPTLTG
SLEKVREQVQAAHALGLTAVISSSIESSLGLTQLARIAAWLTPDTIPGLDTLDLMQAQQV
RRWPGSTLPVVEVDALERLL
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BDBM181040 |
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n/a |
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Name | BDBM181040 |
Synonyms: | 5'-O-(N-[4-(2-(2H-Tetrazol-5-yl)phenyl)-4-oxobutanoyl]sulfamoyl)adenosine (3, Tetrazole) |
Type | Small organic molecule |
Emp. Form. | C21H22N10O8S |
Mol. Mass. | 574.527 |
SMILES | Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COS(=O)(=O)NC(=O)CCC(=O)c2ccccc2-c2nn[nH]n2)[C@@H](O)[C@H]1O |r| |
Structure |
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