| Reaction Details |
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 | Report a problem with these data |
| Target | Ferrochelatase, mitochondrial [R115L] |
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| Ligand | BDBM31340 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Competition Binding Assays |
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| Kd | 2.30e+4±n/a nM |
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| Citation |  Klaeger, S; Gohlke, B; Perrin, J; Gupta, V; Heinzlmeir, S; Helm, D; Qiao, H; Bergamini, G; Handa, H; Savitski, MM; Bantscheff, M; Médard, G; Preissner, R; Kuster, B Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors. ACS Chem Biol11:1245-54 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ferrochelatase, mitochondrial [R115L] |
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| Name: | Ferrochelatase, mitochondrial [R115L] |
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| Synonyms: | FECH | Ferrochelatase R115L (FECH) | HEMH_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 47832.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Mutant R115L used for experiment |
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| Residue: | 423 |
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| Sequence: | MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQV
QPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRLTPKIQ
EQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERD
GLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADH
ILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLV
WQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKEC
GVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTS
QQL
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| BDBM31340 |
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| n/a |
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| Name | BDBM31340 |
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| Synonyms: | 2-methoxy-N-[(E)-3-[4-[3-methyl-4-(6-methylpyridin-3-yl)oxyanilino]quinazolin-6-yl]prop-2-enyl]acetamide | 2-methoxy-N-[(E)-3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide | 2-methoxy-N-[(E)-3-[4-[3-methyl-4-[(6-methyl-3-pyridyl)oxy]anilino]quinazolin-6-yl]allyl]acetamide | 2-methoxy-N-[(E)-3-[4-[[3-methyl-4-(6-methylpyridin-3-yl)oxy-phenyl]amino]quinazolin-6-yl]prop-2-enyl]ethanamide | CHEMBL483321 | CP-724714 | cid_9874913 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H27N5O3 |
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| Mol. Mass. | 469.535 |
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| SMILES | COCC(=O)NC\C=C\c1ccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c2c1 |
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| Structure | 
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