| Reaction Details |
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 | Report a problem with these data |
| Target | Ferrochelatase, mitochondrial [R115L] |
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| Ligand | BDBM25013 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Competition Binding Assays |
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| Kd | 2.7e+3±n/a nM |
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| Citation |  Klaeger, S; Gohlke, B; Perrin, J; Gupta, V; Heinzlmeir, S; Helm, D; Qiao, H; Bergamini, G; Handa, H; Savitski, MM; Bantscheff, M; Médard, G; Preissner, R; Kuster, B Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors. ACS Chem Biol11:1245-54 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ferrochelatase, mitochondrial [R115L] |
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| Name: | Ferrochelatase, mitochondrial [R115L] |
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| Synonyms: | FECH | Ferrochelatase R115L (FECH) | HEMH_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 47832.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Mutant R115L used for experiment |
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| Residue: | 423 |
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| Sequence: | MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQV
QPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRLTPKIQ
EQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERD
GLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADH
ILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLV
WQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKEC
GVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTS
QQL
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| BDBM25013 |
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| n/a |
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| Name | BDBM25013 |
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| Synonyms: | 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-piperidin-3-ylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol | GSK-690693 | GSK690693 | US10550114, Compound GSK690693 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H27N7O3 |
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| Mol. Mass. | 425.4842 |
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| SMILES | CCn1c(nc2c(ncc(OC[C@H]3CCCNC3)c12)C#CC(C)(C)O)-c1nonc1N |r| |
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| Structure | 
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