| Reaction Details |
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 | Report a problem with these data |
| Target | Ferrochelatase, mitochondrial [R115L] |
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| Ligand | BDBM50311017 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Competition Binding Assays |
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| Kd | 3.4e+3±n/a nM |
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| Citation |  Klaeger, S; Gohlke, B; Perrin, J; Gupta, V; Heinzlmeir, S; Helm, D; Qiao, H; Bergamini, G; Handa, H; Savitski, MM; Bantscheff, M; Médard, G; Preissner, R; Kuster, B Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors. ACS Chem Biol11:1245-54 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ferrochelatase, mitochondrial [R115L] |
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| Name: | Ferrochelatase, mitochondrial [R115L] |
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| Synonyms: | FECH | Ferrochelatase R115L (FECH) | HEMH_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 47832.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Mutant R115L used for experiment |
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| Residue: | 423 |
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| Sequence: | MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQV
QPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRLTPKIQ
EQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERD
GLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADH
ILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLV
WQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKEC
GVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTS
QQL
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| BDBM50311017 |
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| n/a |
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| Name | BDBM50311017 |
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| Synonyms: | CHEMBL1078178 | Momelotinib | N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide | US10112907, Example 00019 | US10766894, Compound TABLE 1.4 | US11203595, TABLE 1.4 | US9469613, CYT-0387 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H22N6O2 |
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| Mol. Mass. | 414.4598 |
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| SMILES | O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1 |
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| Structure | 
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