| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ferrochelatase, mitochondrial [R115L] |
|---|
| Ligand | BDBM50237710 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Competition Binding Assays |
|---|
| Kd | 1.7e+3±n/a nM |
|---|
| Citation |  Klaeger, S; Gohlke, B; Perrin, J; Gupta, V; Heinzlmeir, S; Helm, D; Qiao, H; Bergamini, G; Handa, H; Savitski, MM; Bantscheff, M; Médard, G; Preissner, R; Kuster, B Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors. ACS Chem Biol11:1245-54 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ferrochelatase, mitochondrial [R115L] |
|---|
| Name: | Ferrochelatase, mitochondrial [R115L] |
|---|
| Synonyms: | FECH | Ferrochelatase R115L (FECH) | HEMH_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 47832.73 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Mutant R115L used for experiment |
|---|
| Residue: | 423 |
|---|
| Sequence: | MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQV
QPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRLTPKIQ
EQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERD
GLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADH
ILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLV
WQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKEC
GVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTS
QQL
|
|
|
|---|
| BDBM50237710 |
|---|
| n/a |
|---|
| Name | BDBM50237710 |
|---|
| Synonyms: | 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide | AMN 107 | AMN107 | CHEMBL255863 | NILOTINIB | US11649218, Example Nilotinib |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H22F3N7O |
|---|
| Mol. Mass. | 529.5158 |
|---|
| SMILES | Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
