Reaction Details |
| Report a problem with these data |
Target | Ferrochelatase, mitochondrial [R115L] |
---|
Ligand | BDBM60665 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Competition Binding Assays |
---|
Kd | 3.6e+3±n/a nM |
---|
Citation | Klaeger, S; Gohlke, B; Perrin, J; Gupta, V; Heinzlmeir, S; Helm, D; Qiao, H; Bergamini, G; Handa, H; Savitski, MM; Bantscheff, M; Médard, G; Preissner, R; Kuster, B Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors. ACS Chem Biol11:1245-54 (2016) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Ferrochelatase, mitochondrial [R115L] |
---|
Name: | Ferrochelatase, mitochondrial [R115L] |
Synonyms: | FECH | Ferrochelatase R115L (FECH) | HEMH_HUMAN |
Type: | Protein |
Mol. Mass.: | 47832.73 |
Organism: | Homo sapiens (Human) |
Description: | Mutant R115L used for experiment |
Residue: | 423 |
Sequence: | MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQV
QPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRLTPKIQ
EQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERD
GLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADH
ILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLV
WQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKEC
GVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTS
QQL
|
|
|
BDBM60665 |
---|
n/a |
---|
Name | BDBM60665 |
Synonyms: | BDBM50249542 | US9145414, R406 | US9212178, R406 |
Type | n/a |
Emp. Form. | C22H23FN6O5 |
Mol. Mass. | 470.4536 |
SMILES | COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC |
Structure |
|