| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-glutamine gamma-glutamyltransferase E |
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| Ligand | BDBM185163 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TG Activity Assays |
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| IC50 | 6.5e+4±n/a nM |
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| Citation |  Badarau, E; Wang, Z; Rathbone, DL; Costanzi, A; Thibault, T; Murdoch, CE; El Alaoui, S; Bartkeviciute, M; Griffin, M Development of Potent and Selective Tissue Transglutaminase Inhibitors: Their Effect on TG2 Function and Application in Pathological Conditions. Chem Biol22:1347-61 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-glutamine gamma-glutamyltransferase E |
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| Name: | Protein-glutamine gamma-glutamyltransferase E |
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| Synonyms: | Protein-glutamine glutamyltransferase E | TGM3 | TGM3_HUMAN | Transglutaminase-3 (TG3) |
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| Type: | Protein |
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| Mol. Mass.: | 76625.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 693 |
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| Sequence: | MAALGVQSINWQTAFNRQAHHTDKFSSQELILRRGQNFQVLMIMNKGLGSNERLEFIVST
GPYPSESAMTKAVFPLSNGSSGGWSAVLQASNGNTLTISISSPASAPIGRYTMALQIFSQ
GGISSVKLGTFILLFNPWLNVDSVFMGNHAEREEYVQEDAGIIFVGSTNRIGMIGWNFGQ
FEEDILSICLSILDRSLNFRRDAATDVASRNDPKYVGRVLSAMINSNDDNGVLAGNWSGT
YTGGRDPRSWNGSVEILKNWKKSGFSPVRYGQCWVFAGTLNTALRSLGIPSRVITNFNSA
HDTDRNLSVDVYYDPMGNPLDKGSDSVWNFHVWNEGWFVRSDLGPSYGGWQVLDATPQER
SQGVFQCGPASVIGVREGDVQLNFDMPFIFAEVNADRITWLYDNTTGKQWKNSVNSHTIG
RYISTKAVGSNARMDVTDKYKYPEGSDQERQVFQKALGKLKPNTPFAATSSMGLETEEQE
PSIIGKLKVAGMLAVGKEVNLVLLLKNLSRDTKTVTVNMTAWTIIYNGTLVHEVWKDSAT
MSLDPEEEAEHPIKISYAQYEKYLKSDNMIRITAVCKVPDESEVVVERDIILDNPTLTLE
VLNEARVRKPVNVQMLFSNPLDEPVRDCVLMVEGSGLLLGNLKIDVPTLGPKEGSRVRFD
ILPSRSGTKQLLADFSCNKFPAIKAMLSIDVAE
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| BDBM185163 |
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| n/a |
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| Name | BDBM185163 |
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| Synonyms: | (6-Methoxycarbonyl-2-naphthyl)methyl 4-[2-[(2-bromoacetyl)amino]acetyl]piperazine-1-carboxylate (6d) |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24BrN3O6 |
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| Mol. Mass. | 506.346 |
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| SMILES | COC(=O)c1ccc2cc(COC(=O)N3CCN(CC3)C(=O)CNC(=O)CBr)ccc2c1 |
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| Structure | 
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