| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase ABL1 [229-512] |
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| Ligand | BDBM185674 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinome-Wide Inhibitor Profiling |
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| Kd | 7.2±0.1 nM |
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| Citation |  Kwarcinski, FE; Brandvold, KR; Phadke, S; Beleh, OM; Johnson, TK; Meagher, JL; Seeliger, MA; Stuckey, JA; Soellner, MB Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity. ACS Chem Biol11:1296-304 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Tyrosine-protein kinase ABL1 [229-512] |
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| Name: | Tyrosine-protein kinase ABL1 [229-512] |
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| Synonyms: | ABL | ABL1 | ABL1_HUMAN | JTK7 | Tyrosine-protein kinase ABL1 (c-Abl) |
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| Type: | Protein |
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| Mol. Mass.: | 32850.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human c-Abl kinase domain (229-512aa) |
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| Residue: | 284 |
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| Sequence: | SPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA
VMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQIS
SAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP
ESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV
YELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGK
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| BDBM185674 |
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| n/a |
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| Name | BDBM185674 |
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| Synonyms: | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpyrazol-3-yl)carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide | Rebastinib |
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| Type | Small organic molecule |
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| Emp. Form. | C30H28FN7O3 |
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| Mol. Mass. | 553.5868 |
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| SMILES | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc4ncccc4c3)C(C)(C)C)c(F)c2)ccn1 |
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| Structure | 
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