Reaction Details |
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Target | Glycogen synthase kinase-3 alpha |
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Ligand | BDBM60933 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Mobility Shift Microfluidics Assay |
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pH | 7.5±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 8± 3 nM |
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Comments | extracted |
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Citation | Wagner, FF; Bishop, JA; Gale, JP; Shi, X; Walk, M; Ketterman, J; Patnaik, D; Barker, D; Walpita, D; Campbell, AJ; Nguyen, S; Lewis, M; Ross, L; Weïwer, M; An, WF; Germain, AR; Nag, PP; Metkar, S; Kaya, T; Dandapani, S; Olson, DE; Barbe, AL; Lazzaro, F; Sacher, JR; Cheah, JH; Fei, D; Perez, J; Munoz, B; Palmer, M; Stegmaier, K; Schreiber, SL; Scolnick, E; Zhang, YL; Haggarty, SJ; Holson, EB; Pan, JQ Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects. ACS Chem Biol11:1952-63 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glycogen synthase kinase-3 alpha |
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Name: | Glycogen synthase kinase-3 alpha |
Synonyms: | GSK-3 alpha | GSK3A | GSK3A_HUMAN | Glycogen synthase kinase 3 alpha (GSKalpha) | Glycogen synthase kinase-3 | Glycogen synthase kinase-3 alpha | Glycogen synthase kinase-3 alpha (GSK3 Alpha) | Glycogen synthase kinase-3 alpha (GSK3A) | Glycogen synthase kinase-3 alpha (GSK3alpha) |
Type: | Enzyme |
Mol. Mass.: | 50991.79 |
Organism: | Homo sapiens (Human) |
Description: | P49840 |
Residue: | 483 |
Sequence: | MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGV
GASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT
DIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY
SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGV
CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS
IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK
AHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLP
PLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLT
NSS
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BDBM60933 |
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n/a |
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Name | BDBM60933 |
Synonyms: | (S)-3,4,7,7-tetramethyl-4-phenyl-2,4,6,7,8,9-hexahydro-5H-pyrazolo[3,4-b]quinolin-5-one (16) | US10137122, Compound 123 |
Type | n/a |
Emp. Form. | C20H23N3O |
Mol. Mass. | 321.4161 |
SMILES | Cc1[nH]nc2NC3=C(C(=O)CC(C)(C)C3)[C@](C)(c12)c1ccccc1 |r,t:6| |
Structure |
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