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TargetGlycogen synthase kinase-3
LigandBDBM188514
Substrate/Competitorn/a
Meas. Tech.Mobility Shift Microfluidics Assay
pH7.5±n/a
Temperature298.15±n/a K
IC50 0.4± 0.1 nM
Commentsextracted
Citation Wagner FFBishop JAGale JPShi XWalk MKetterman JPatnaik DBarker DWalpita DCampbell AJNguyen SLewis MRoss LWe´wer MAn WFGermain ARNag PPMetkar SKaya TDandapani SOlson DEBarbe ALLazzaro FSacher JRCheah JHFei DPerez JMunoz BPalmer MStegmaier KSchreiber SLScolnick EZhang YLHaggarty SJHolson EBPan JQ Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects. ACS Chem Biol 11:1952-63 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glycogen synthase kinase-3
Name:Glycogen synthase kinase-3
Synonyms:GSK-3 alpha | GSK3A | Glycogen synthase kinase 3 alpha (GSKalpha) | Glycogen synthase kinase-3 alpha | Glycogen synthase kinase-3 alpha (GSK3 Alpha) | Glycogen synthase kinase-3 alpha (GSK3A) | Glycogen synthase kinase-3 alpha (GSK3a) | Glycogen synthase kinase-3 alpha (GSK3alpha)
Type:Enzyme
Mol. Mass.:50991.79
Organism:Homo sapiens (Human)
Description:P49840
Residue:483
Sequence:
MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGV
GASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT
DIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY
SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGV
CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS
IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK
AHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLP
PLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLT
NSS
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  Blast E-value cutoff:
BDBM188514
n/a
NameBDBM188514
Synonyms:4,7,7-trimethyl-4-phenyl-3-(trifluoromethyl)-2,4,6,7,8,9-hexahydro-5H-pyrazolo[3,4-b]quinolin-5-one (BRD1652) | US10137122, Compound 70
TypeSmall organic molecule
Emp. Form.C20H20F3N3O
Mol. Mass.375.3875
SMILESCC1(C)CC(=O)C2=C(C1)Nc1n[nH]c(c1[C@]2(C)c1ccccc1)C(F)(F)F |r,c:6|
Structure
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