| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific demethylase 5A [1-739] |
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| Ligand | BDBM191603 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Formaldehyde Dehydrogenase-Coupled Demethylase (FDH) Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | >2.00e+5±n/a nM |
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| Comments | extracted |
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| Citation |  Horton, JR; Liu, X; Gale, M; Wu, L; Shanks, JR; Zhang, X; Webber, PJ; Bell, JS; Kales, SC; Mott, BT; Rai, G; Jansen, DJ; Henderson, MJ; Urban, DJ; Hall, MD; Simeonov, A; Maloney, DJ; Johns, MA; Fu, H; Jadhav, A; Vertino, PM; Yan, Q; Cheng, X Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol23:769-81 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific demethylase 5A [1-739] |
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| Name: | Lysine-specific demethylase 5A [1-739] |
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| Synonyms: | JARID1A | KDM5A | KDM5A_HUMAN | Lysine-specific demethylase 5A (KDM5A(aa 1-739)-AP(2C-2S)) | RBBP2 | RBP2 |
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| Type: | Protein |
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| Mol. Mass.: | 84420.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Truncation 1-739 aa. Contains deletion of ARID and PhD1 domains. |
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| Residue: | 739 |
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| Sequence: | MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPP
FACEVKSFRFTPRVQRLNELEAMTRVRLDFLDQLAKFWELQGSTLKIPVVERKILDLYAL
SKIVASKGGFEMVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMG
VQMPNLDLKEKVEPEVLSTDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSRNTELKKLQ
IFGAGPKVVGLAMGTKDKEDEVTRRRKVTNRSDAFNMQMRQRKGTLSVNFVDLYVCMFCG
RGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFEQAVRE
YTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGS
GFPVKDGRRKILPEEEEYALSGWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSF
CWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIM
NPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVN
HYRRLRRHCVFSHEELIFKMAADPECLDVGLAAMVCKELTLMTEEETRLRESVVQMGVLM
SEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRY
PLEDLPSLLYGVKVRAQSY
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| BDBM191603 |
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| n/a |
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| Name | BDBM191603 |
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| Synonyms: | methyl 4'-(phenethylcarbamoyl)-[2,2'-bipyridine]-4-carboxylate (N4) |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19N3O3 |
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| Mol. Mass. | 361.3939 |
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| SMILES | COC(=O)c1ccnc(c1)-c1cc(ccn1)C(=O)NCCc1ccccc1 |
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| Structure | 
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