| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 1 [8-360] |
|---|
| Ligand | BDBM192378 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzymatic Assay |
|---|
| pH | 7.3±n/a |
|---|
| IC50 | 20±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Blake, JF; Chen, H; Chicarelli, MJ; Demeese, J; Garrey, RF; Gaudino, J; Gazzard, L; Kaus, RJ; Kintz, S; Mohr, PJ; Moreno, DA; Schwarz, J; Siedem, CS; Wallace, EM Substituted quinazolines as serine/threonine kinase inhibitors US Patent US9187462 Publication Date 11/17/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase 1 [8-360] |
|---|
| Name: | Mitogen-activated protein kinase 1 [8-360] |
|---|
| Synonyms: | ERK2 | Human ERK-2 | MAPK1 | MK01_HUMAN | Mitogen Activated Kinase 1 | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (aa 8-360) | PRKM1 | PRKM2 |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 40835.09 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P28482 aa 8-360 |
|---|
| Residue: | 353 |
|---|
| Sequence: | GAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQR
TLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHIC
YFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEY
VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSP
SQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQA
LAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
|
|
|
|---|
| BDBM192378 |
|---|
| n/a |
|---|
| Name | BDBM192378 |
|---|
| Synonyms: | US9187462, I-58 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H24F2N6O3 |
|---|
| Mol. Mass. | 482.4826 |
|---|
| SMILES | COCCNc1ncc2c(F)cc(cc2n1)C(=O)N[C@H](c1cnn(C)c1)c1ccc(OC)c(F)c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
