Compile Data Set for Download or QSAR

Found 224 hits with Last Name = 'kaus' and Initial = 'rj'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192361 (US9187462, I-41) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(OC(F)F)cc1 |r| Show InChI InChI=1S/C26H26F2N6O3/c1-34-15-19(14-30-34)23(16-4-6-21(7-5-16)37-25(27)28)33-24(35)17-2-3-18-13-29-26(32-22(18)12-17)31-20-8-10-36-11-9-20/h2-7,12-15,20,23,25H,8-11H2,1H3,(H,33,35)(H,29,31,32)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.550	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM180948 (US9133187, I-59) Show SMILES Fc1ccc(cc1Cl)[C@@H](CC#N)NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1 |r| Show InChI InChI=1S/C22H24ClFN6O2/c23-17-11-14(1-2-18(17)24)19(3-7-25)29-22(31)30-8-4-15-12-26-21(28-20(15)13-30)27-16-5-9-32-10-6-16/h1-2,11-12,16,19H,3-6,8-10,13H2,(H,29,31)(H,26,27,28)/t19-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.3	n/a
ARRAY BIOPHARMA INC.; GENENTECH, INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9133187 (2015) BindingDB Entry DOI: 10.7270/Q28W3C2N
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192386 (US9187462, I-66) Show SMILES COc1ccc(cc1Cl)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cnn(C)c1 |r| Show InChI InChI=1S/C26H26ClFN6O3/c1-34-14-17(12-30-34)24(15-3-4-23(36-2)20(27)9-15)33-25(35)16-10-21(28)19-13-29-26(32-22(19)11-16)31-18-5-7-37-8-6-18/h3-4,9-14,18,24H,5-8H2,1-2H3,(H,33,35)(H,29,31,32)/t24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192385 (US9187462, I-65) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1ccc(C#N)c(Cl)c1 |r| Show InChI InChI=1S/C26H23ClFN7O2/c1-35-14-18(12-31-35)24(15-2-3-16(11-29)21(27)8-15)34-25(36)17-9-22(28)20-13-30-26(33-23(20)10-17)32-19-4-6-37-7-5-19/h2-3,8-10,12-14,19,24H,4-7H2,1H3,(H,34,36)(H,30,32,33)/t24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM180995 (US9133187, II-171) Show SMILES C[C@@H](CO)Nc1ncc2CCN(Cc2n1)C(=O)N[C@@H]1CNC[C@H]1c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C22H27F3N6O2/c1-13(12-32)28-20-27-8-15-6-7-31(11-19(15)29-20)21(33)30-18-10-26-9-17(18)14-2-4-16(5-3-14)22(23,24)25/h2-5,8,13,17-18,26,32H,6-7,9-12H2,1H3,(H,30,33)(H,27,28,29)/t13-,17-,18+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	7.3	n/a
ARRAY BIOPHARMA INC.; GENENTECH, INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9133187 (2015) BindingDB Entry DOI: 10.7270/Q28W3C2N
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192322 (US9187462, I-2) Show SMILES Cn1cc(cn1)C(NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C25H24ClFN6O2/c1-33-14-18(13-29-33)23(15-4-5-20(26)21(27)10-15)32-24(34)16-2-3-17-12-28-25(31-22(17)11-16)30-19-6-8-35-9-7-19/h2-5,10-14,19,23H,6-9H2,1H3,(H,32,34)(H,28,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192364 (US9187462, I-44) Show SMILES COc1ccc(cc1Cl)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1cnn(C)c1 |r| Show InChI InChI=1S/C26H27ClN6O3/c1-33-15-19(14-29-33)24(16-5-6-23(35-2)21(27)11-16)32-25(34)17-3-4-18-13-28-26(31-22(18)12-17)30-20-7-9-36-10-8-20/h3-6,11-15,20,24H,7-10H2,1-2H3,(H,32,34)(H,28,30,31)/t24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192368 (US9187462, I-48) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(C#N)c(Cl)c1 |r| Show InChI InChI=1S/C26H24ClN7O2/c1-34-15-20(14-30-34)24(16-2-4-18(12-28)22(27)10-16)33-25(35)17-3-5-19-13-29-26(32-23(19)11-17)31-21-6-8-36-9-7-21/h2-5,10-11,13-15,21,24H,6-9H2,1H3,(H,33,35)(H,29,31,32)/t24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192352 (US9187462, I-32) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1cnn(C)c1 |r| Show InChI InChI=1S/C26H27FN6O3/c1-33-15-19(14-29-33)24(16-5-6-23(35-2)21(27)11-16)32-25(34)17-3-4-18-13-28-26(31-22(18)12-17)30-20-7-9-36-10-8-20/h3-6,11-15,20,24H,7-10H2,1-2H3,(H,32,34)(H,28,30,31)/t24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM180935 (US9133187, I-15) Show SMILES CC(C)Nc1ncc2CCN(Cc2n1)C(=O)NC([C@H]1CCCN1)c1ccc(c(F)c1)C(F)(F)F |r| Show InChI InChI=1S/C23H28F4N6O/c1-13(2)30-21-29-11-15-7-9-33(12-19(15)31-21)22(34)32-20(18-4-3-8-28-18)14-5-6-16(17(24)10-14)23(25,26)27/h5-6,10-11,13,18,20,28H,3-4,7-9,12H2,1-2H3,(H,32,34)(H,29,30,31)/t18-,20?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	7.3	n/a
ARRAY BIOPHARMA INC.; GENENTECH, INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9133187 (2015) BindingDB Entry DOI: 10.7270/Q28W3C2N
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM180929 (US9133187, I-1) Show SMILES Clc1ccc(cc1Cl)[C@H](NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1cnco1 |r| Show InChI InChI=1S/C23H24Cl2N6O3/c24-17-2-1-14(9-18(17)25)21(20-11-26-13-34-20)30-23(32)31-6-3-15-10-27-22(29-19(15)12-31)28-16-4-7-33-8-5-16/h1-2,9-11,13,16,21H,3-8,12H2,(H,30,32)(H,27,28,29)/t21-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	7.3	n/a
ARRAY BIOPHARMA INC.; GENENTECH, INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9133187 (2015) BindingDB Entry DOI: 10.7270/Q28W3C2N
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192436 (US9187462, II-46) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cncn1C |r| Show InChI InChI=1S/C26H26F2N6O3/c1-34-14-29-13-22(34)24(15-3-4-23(36-2)20(28)9-15)33-25(35)16-10-19(27)18-12-30-26(32-21(18)11-16)31-17-5-7-37-8-6-17/h3-4,9-14,17,24H,5-8H2,1-2H3,(H,33,35)(H,30,31,32)/t24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM180942 (US9133187, I-33) Show SMILES C[C@@H](CO)Nc1ncc2CCN(Cc2n1)C(=O)N[C@H](CCO)c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C20H25Cl2N5O3/c1-12(11-29)24-19-23-9-14-4-6-27(10-18(14)25-19)20(30)26-17(5-7-28)13-2-3-15(21)16(22)8-13/h2-3,8-9,12,17,28-29H,4-7,10-11H2,1H3,(H,26,30)(H,23,24,25)/t12-,17+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	7.3	n/a
ARRAY BIOPHARMA INC.; GENENTECH, INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9133187 (2015) BindingDB Entry DOI: 10.7270/Q28W3C2N
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM180936 (US9133187, I-16) Show SMILES CC(C)Nc1ncc2CCN(Cc2n1)C(=O)N[C@H](CO)c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C19H23Cl2N5O2/c1-11(2)23-18-22-8-13-5-6-26(9-16(13)24-18)19(28)25-17(10-27)12-3-4-14(20)15(21)7-12/h3-4,7-8,11,17,27H,5-6,9-10H2,1-2H3,(H,25,28)(H,22,23,24)/t17-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	7.3	n/a
ARRAY BIOPHARMA INC.; GENENTECH, INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9133187 (2015) BindingDB Entry DOI: 10.7270/Q28W3C2N
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192389 (US9187462, I-69) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(N[C@H]3CC[C@H](O)CC3)nc2c1)c1cnn(C)c1 |r,wU:22.22,wD:9.10,25.26,(11.38,-2.65,;10.05,-3.42,;8.72,-2.65,;7.34,-3.39,;6,-2.62,;6,-1.08,;7.34,-.31,;8.67,-1.08,;10,-.31,;4.67,-.31,;3.33,-1.08,;2,-.31,;2,1.23,;.67,-1.08,;.67,-2.62,;-.67,-3.39,;-.67,-4.93,;-2,-2.62,;-3.33,-3.39,;-4.67,-2.62,;-4.67,-1.08,;-6,-.31,;-7.34,-1.08,;-7.34,-2.62,;-8.67,-3.39,;-10,-2.62,;-11.34,-3.39,;-10,-1.08,;-8.67,-.31,;-3.33,-.31,;-2,-1.08,;-.67,-.31,;4.67,1.23,;3.42,2.13,;3.9,3.6,;5.46,3.63,;6.37,4.88,;5.91,2.13,)| Show InChI InChI=1S/C27H28F2N6O3/c1-35-14-17(12-31-35)25(15-3-8-24(38-2)22(29)9-15)34-26(37)16-10-21(28)20-13-30-27(33-23(20)11-16)32-18-4-6-19(36)7-5-18/h3,8-14,18-19,25,36H,4-7H2,1-2H3,(H,34,37)(H,30,32,33)/t18-,19-,25-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192388 (BDBM192402 | US9187462, I-68) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cccc(F)c1 |r| Show InChI InChI=1S/C25H24F2N6O2/c1-33-14-17(12-29-33)23(15-3-2-4-18(26)9-15)32-24(34)16-10-21(27)20-13-28-25(31-22(20)11-16)30-19-5-7-35-8-6-19/h2-4,9-14,19,23H,5-8H2,1H3,(H,32,34)(H,28,30,31)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192359 (US9187462, I-39) Show SMILES Fc1ccc(cc1Cl)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@@]1(F)CCNC1 |r| Show InChI InChI=1S/C25H26ClF2N5O2/c26-19-11-15(3-4-20(19)27)22(25(28)7-8-29-14-25)33-23(34)16-1-2-17-13-30-24(32-21(17)12-16)31-18-5-9-35-10-6-18/h1-4,11-13,18,22,29H,5-10,14H2,(H,33,34)(H,30,31,32)/t22-,25+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192403 (US9187462, II-13) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(N[C@H]3CC[C@H](O)CC3)nc2c1)c1cnn(C)c1 |r,wU:22.22,9.10,wD:25.26,(9.38,1.49,;8.05,2.26,;6.72,1.49,;5.33,2.24,;4,1.47,;4,-.07,;5.33,-.84,;6.67,-.07,;8,-.84,;2.67,-.84,;1.33,-.07,;1.33,1.47,;2.67,2.24,;,2.24,;,3.78,;-1.33,4.55,;-1.33,6.09,;-2.67,3.78,;-4,4.55,;-5.33,3.78,;-5.33,2.24,;-6.67,1.47,;-6.67,-.07,;-5.33,-.84,;-5.33,-2.38,;-6.67,-3.15,;-6.67,-4.69,;-8,-2.38,;-8,-.84,;-4,1.47,;-2.67,2.24,;-1.33,1.47,;2.67,-2.38,;3.91,-3.29,;3.44,-4.75,;1.87,-4.79,;.97,-6.03,;1.42,-3.29,)| Show InChI InChI=1S/C27H28F2N6O3/c1-35-14-17(12-31-35)25(15-3-8-24(38-2)22(29)9-15)34-26(37)16-10-21(28)20-13-30-27(33-23(20)11-16)32-18-4-6-19(36)7-5-18/h3,8-14,18-19,25,36H,4-7H2,1-2H3,(H,34,37)(H,30,32,33)/t18-,19-,25-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192335 (US9187462, I-15) Show SMILES CC(CO)Nc1ncc2ccc(cc2n1)C(=O)N[C@H](c1cnn(C)c1)c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C23H22ClFN6O2/c1-13(12-32)28-23-26-9-16-4-3-15(8-20(16)29-23)22(33)30-21(17-10-27-31(2)11-17)14-5-6-18(24)19(25)7-14/h3-11,13,21,32H,12H2,1-2H3,(H,30,33)(H,26,28,29)/t13?,21-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192437 (US9187462, II-47) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cnco1 |r| Show InChI InChI=1S/C25H23F2N5O4/c1-34-21-3-2-14(8-19(21)27)23(22-12-28-13-36-22)32-24(33)15-9-18(26)17-11-29-25(31-20(17)10-15)30-16-4-6-35-7-5-16/h2-3,8-13,16,23H,4-7H2,1H3,(H,32,33)(H,29,30,31)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192388 (BDBM192402 | US9187462, I-68) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cccc(F)c1 |r| Show InChI InChI=1S/C25H24F2N6O2/c1-33-14-17(12-29-33)23(15-3-2-4-18(26)9-15)32-24(34)16-10-21(27)20-13-28-25(31-22(20)11-16)30-19-5-7-35-8-6-19/h2-4,9-14,19,23H,5-8H2,1H3,(H,32,34)(H,28,30,31)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192438 (US9187462, II-48) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cnnn1C |r| Show InChI InChI=1S/C25H25F2N7O3/c1-34-21(13-29-33-34)23(14-3-4-22(36-2)19(27)9-14)32-24(35)15-10-18(26)17-12-28-25(31-20(17)11-15)30-16-5-7-37-8-6-16/h3-4,9-13,16,23H,5-8H2,1-2H3,(H,32,35)(H,28,30,31)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192367 (US9187462, I-47) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(N[C@@H]3CCO[C@H](CO)C3)nc2c1)c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C26H26ClFN6O3/c1-34-13-18(12-30-34)24(15-4-5-21(27)22(28)8-15)33-25(36)16-2-3-17-11-29-26(32-23(17)9-16)31-19-6-7-37-20(10-19)14-35/h2-5,8-9,11-13,19-20,24,35H,6-7,10,14H2,1H3,(H,33,36)(H,29,31,32)/t19-,20+,24+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM180931 (US9133187, I-5) Show SMILES Cn1cc(cn1)C(NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C24H27ClFN7O2/c1-32-13-17(12-28-32)22(15-2-3-19(25)20(26)10-15)31-24(34)33-7-4-16-11-27-23(30-21(16)14-33)29-18-5-8-35-9-6-18/h2-3,10-13,18,22H,4-9,14H2,1H3,(H,31,34)(H,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.3	n/a
ARRAY BIOPHARMA INC.; GENENTECH, INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9133187 (2015) BindingDB Entry DOI: 10.7270/Q28W3C2N
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192332 (US9187462, I-12) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C25H24ClFN6O2/c1-33-14-18(13-29-33)23(15-4-5-20(26)21(27)10-15)32-24(34)16-2-3-17-12-28-25(31-22(17)11-16)30-19-6-8-35-9-7-19/h2-5,10-14,19,23H,6-9H2,1H3,(H,32,34)(H,28,30,31)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192342 (US9187462, I-22) Show SMILES Cn1ccc(n1)[C@@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C25H23ClF2N6O2/c1-34-7-4-21(33-34)23(14-2-3-18(26)20(28)10-14)32-24(35)15-11-19(27)17-13-29-25(31-22(17)12-15)30-16-5-8-36-9-6-16/h2-4,7,10-13,16,23H,5-6,8-9H2,1H3,(H,32,35)(H,29,30,31)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192443 (US9187462, II-53) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(Nc3ccnn3C)nc2c1)c1cncn1C |r| Show InChI InChI=1S/C25H22F2N8O2/c1-34-13-28-12-20(34)23(14-4-5-21(37-3)18(27)8-14)33-24(36)15-9-17(26)16-11-29-25(31-19(16)10-15)32-22-6-7-30-35(22)2/h4-13,23H,1-3H3,(H,33,36)(H,29,31,32)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM180940 (US9133187, I-27) Show SMILES CC[C@@H](NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1ccc(OC(F)F)cc1 |r| Show InChI InChI=1S/C23H29F2N5O3/c1-2-19(15-3-5-18(6-4-15)33-21(24)25)29-23(31)30-10-7-16-13-26-22(28-20(16)14-30)27-17-8-11-32-12-9-17/h3-6,13,17,19,21H,2,7-12,14H2,1H3,(H,29,31)(H,26,27,28)/t19-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.3	n/a
ARRAY BIOPHARMA INC.; GENENTECH, INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9133187 (2015) BindingDB Entry DOI: 10.7270/Q28W3C2N
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192353 (US9187462, I-33) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cnn(C)c1 |r| Show InChI InChI=1S/C26H26F2N6O3/c1-34-14-17(12-30-34)24(15-3-4-23(36-2)21(28)9-15)33-25(35)16-10-20(27)19-13-29-26(32-22(19)11-16)31-18-5-7-37-8-6-18/h3-4,9-14,18,24H,5-8H2,1-2H3,(H,33,35)(H,29,31,32)/t24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM180932 (US9133187, I-7) Show SMILES Fc1cc(ccc1Cl)C(NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1cn[nH]c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.3	n/a
ARRAY BIOPHARMA INC.; GENENTECH, INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9133187 (2015) BindingDB Entry DOI: 10.7270/Q28W3C2N
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM180945 (US9133187, I-50) Show SMILES C[C@@H](NC(=O)N1Cc2nc(NC3CCOCC3)ncc2C(F)(F)C1)c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C21H23Cl2F2N5O2/c1-12(13-2-3-16(22)17(23)8-13)27-20(31)30-10-18-15(21(24,25)11-30)9-26-19(29-18)28-14-4-6-32-7-5-14/h2-3,8-9,12,14H,4-7,10-11H2,1H3,(H,27,31)(H,26,28,29)/t12-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.3	n/a
ARRAY BIOPHARMA INC.; GENENTECH, INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9133187 (2015) BindingDB Entry DOI: 10.7270/Q28W3C2N
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM180938 (US9133187, I-21) Show SMILES C[C@@H](CO)Nc1ncc2CCN(Cc2n1)C(=O)N[C@H](C)c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C19H23ClFN5O2/c1-11(10-27)23-18-22-8-14-5-6-26(9-17(14)25-18)19(28)24-12(2)13-3-4-15(20)16(21)7-13/h3-4,7-8,11-12,27H,5-6,9-10H2,1-2H3,(H,24,28)(H,22,23,25)/t11-,12+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.3	n/a
ARRAY BIOPHARMA INC.; GENENTECH, INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9133187 (2015) BindingDB Entry DOI: 10.7270/Q28W3C2N
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM180941 (US9133187, I-28) Show SMILES COCCC(NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C23H29Cl2N5O3/c1-32-9-7-20(15-2-3-18(24)19(25)12-15)29-23(31)30-8-4-16-13-26-22(28-21(16)14-30)27-17-5-10-33-11-6-17/h2-3,12-13,17,20H,4-11,14H2,1H3,(H,29,31)(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.3	n/a
ARRAY BIOPHARMA INC.; GENENTECH, INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9133187 (2015) BindingDB Entry DOI: 10.7270/Q28W3C2N
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM180967 (US9133187, I-120) Show SMILES CC(C)Nc1ncc2CCN(Cc2n1)C(=O)N[C@@H]1CN(C)C[C@H]1c1ccc(c(F)c1)C(F)(F)F |r| Show InChI InChI=1S/C23H28F4N6O/c1-13(2)29-21-28-9-15-6-7-33(12-19(15)30-21)22(34)31-20-11-32(3)10-16(20)14-4-5-17(18(24)8-14)23(25,26)27/h4-5,8-9,13,16,20H,6-7,10-12H2,1-3H3,(H,31,34)(H,28,29,30)/t16-,20+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.3	n/a
ARRAY BIOPHARMA INC.; GENENTECH, INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9133187 (2015) BindingDB Entry DOI: 10.7270/Q28W3C2N
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192356 (US9187462, I-36) Show SMILES Fc1ccc(cc1Cl)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@]1(F)CCNC1 |r| Show InChI InChI=1S/C25H26ClF2N5O2/c26-19-11-15(3-4-20(19)27)22(25(28)7-8-29-14-25)33-23(34)16-1-2-17-13-30-24(32-21(17)12-16)31-18-5-9-35-10-6-18/h1-4,11-13,18,22,29H,5-10,14H2,(H,33,34)(H,30,31,32)/t22-,25-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192351 (US9187462, I-31) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@H]1C[C@H](F)CN1 |r| Show InChI InChI=1S/C26H29F2N5O3/c1-35-23-5-4-15(10-20(23)28)24(22-12-18(27)14-29-22)33-25(34)16-2-3-17-13-30-26(32-21(17)11-16)31-19-6-8-36-9-7-19/h2-5,10-11,13,18-19,22,24,29H,6-9,12,14H2,1H3,(H,33,34)(H,30,31,32)/t18-,22+,24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM180966 (US9133187, I-119) Show SMILES CC(C)Nc1ncc2CCN(Cc2n1)C(=O)NC(CCN)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C21H27F3N6O/c1-13(2)27-19-26-11-15-8-10-30(12-18(15)28-19)20(31)29-17(7-9-25)14-3-5-16(6-4-14)21(22,23)24/h3-6,11,13,17H,7-10,12,25H2,1-2H3,(H,29,31)(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.3	n/a
ARRAY BIOPHARMA INC.; GENENTECH, INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9133187 (2015) BindingDB Entry DOI: 10.7270/Q28W3C2N
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192327 (US9187462, I-7) Show SMILES Fc1cc(ccc1C(F)(F)F)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@H]1CCCN1 |r| Show InChI InChI=1S/C26H27F4N5O2/c27-20-12-15(5-6-19(20)26(28,29)30)23(21-2-1-9-31-21)35-24(36)16-3-4-17-14-32-25(34-22(17)13-16)33-18-7-10-37-11-8-18/h3-6,12-14,18,21,23,31H,1-2,7-11H2,(H,35,36)(H,32,33,34)/t21-,23+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM50021736 (CHEMBL3297855 | US9133187, II-7) Show SMILES CC(C)Nc1ncc2CCN(Cc2n1)C(=O)N[C@H](CN)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C19H24ClFN6O/c1-11(2)24-18-23-9-13-5-6-27(10-17(13)25-18)19(28)26-16(8-22)12-3-4-15(21)14(20)7-12/h3-4,7,9,11,16H,5-6,8,10,22H2,1-2H3,(H,26,28)(H,23,24,25)/t16-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	7.3	n/a
ARRAY BIOPHARMA INC.; GENENTECH, INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9133187 (2015) BindingDB Entry DOI: 10.7270/Q28W3C2N
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192442 (US9187462, II-52) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1nccn1C |r| Show InChI InChI=1S/C26H26F2N6O3/c1-34-8-7-29-24(34)23(15-3-4-22(36-2)20(28)11-15)33-25(35)16-12-19(27)18-14-30-26(32-21(18)13-16)31-17-5-9-37-10-6-17/h3-4,7-8,11-14,17,23H,5-6,9-10H2,1-2H3,(H,33,35)(H,30,31,32)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192346 (US9187462, I-26) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1ccc2cnc(N[C@H](C)C3CC3)nc2c1)[C@H]1CCCN1 |r| Show InChI InChI=1S/C26H30FN5O2/c1-15(16-5-6-16)30-26-29-14-19-8-7-18(13-22(19)31-26)25(33)32-24(21-4-3-11-28-21)17-9-10-23(34-2)20(27)12-17/h7-10,12-16,21,24,28H,3-6,11H2,1-2H3,(H,32,33)(H,29,30,31)/t15-,21-,24+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192355 (US9187462, I-35) Show SMILES C[C@@H]1CC[C@@H](N1)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C26H29ClFN5O2/c1-15-2-7-22(30-15)24(16-5-6-20(27)21(28)12-16)33-25(34)17-3-4-18-14-29-26(32-23(18)13-17)31-19-8-10-35-11-9-19/h3-6,12-15,19,22,24,30H,2,7-11H2,1H3,(H,33,34)(H,29,31,32)/t15-,22-,24+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192340 (US9187462, I-20) Show SMILES Cn1ccc(n1)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C25H24ClFN6O2/c1-33-9-6-21(32-33)23(15-4-5-19(26)20(27)12-15)31-24(34)16-2-3-17-14-28-25(30-22(17)13-16)29-18-7-10-35-11-8-18/h2-6,9,12-14,18,23H,7-8,10-11H2,1H3,(H,31,34)(H,28,29,30)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192381 (US9187462, I-61) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(N[C@@H]3CCOC3)nc2c1)c1cnn(C)c1 |r| Show InChI InChI=1S/C25H24F2N6O3/c1-33-12-16(10-29-33)23(14-3-4-22(35-2)20(27)7-14)32-24(34)15-8-19(26)18-11-28-25(31-21(18)9-15)30-17-5-6-36-13-17/h3-4,7-12,17,23H,5-6,13H2,1-2H3,(H,32,34)(H,28,30,31)/t17-,23+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192323 (US9187462, I-3) Show SMILES Fc1cc(ccc1C(F)(F)F)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@@H]1CCCN1 |r| Show InChI InChI=1S/C26H27F4N5O2/c27-20-12-15(5-6-19(20)26(28,29)30)23(21-2-1-9-31-21)35-24(36)16-3-4-17-14-32-25(34-22(17)13-16)33-18-7-10-37-11-8-18/h3-6,12-14,18,21,23,31H,1-2,7-11H2,(H,35,36)(H,32,33,34)/t21-,23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192350 (US9187462, I-30) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(N[C@@H]3CCOC[C@H]3F)nc2c1)c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C25H23ClF2N6O2/c1-34-12-17(11-30-34)23(14-4-5-18(26)19(27)8-14)33-24(35)15-2-3-16-10-29-25(32-22(16)9-15)31-21-6-7-36-13-20(21)28/h2-5,8-12,20-21,23H,6-7,13H2,1H3,(H,33,35)(H,29,31,32)/t20-,21-,23+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM180959 (US9133187, I-90) Show SMILES C[C@@H](CO)Nc1ncc2CCN(Cc2n1)C(=O)NCc1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C18H21Cl2N5O2/c1-11(10-26)23-17-21-8-13-4-5-25(9-16(13)24-17)18(27)22-7-12-2-3-14(19)15(20)6-12/h2-3,6,8,11,26H,4-5,7,9-10H2,1H3,(H,22,27)(H,21,23,24)/t11-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	7.3	n/a
ARRAY BIOPHARMA INC.; GENENTECH, INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9133187 (2015) BindingDB Entry DOI: 10.7270/Q28W3C2N
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192408 (US9187462, II-18) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1ccc2cnc(Nc3cc(C)nn3C)nc2c1)c1cnn(C)c1 |r| Show InChI InChI=1S/C26H25FN8O2/c1-15-9-23(35(3)33-15)31-26-28-12-18-6-5-17(11-21(18)30-26)25(36)32-24(19-13-29-34(2)14-19)16-7-8-22(37-4)20(27)10-16/h5-14,24H,1-4H3,(H,32,36)(H,28,30,31)/t24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192406 (US9187462, II-16) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1ccc2cnc(Nc3ccnn3C)nc2c1)c1cnn(C)c1 |r| Show InChI InChI=1S/C25H23FN8O2/c1-33-14-18(13-29-33)23(15-6-7-21(36-3)19(26)10-15)32-24(35)16-4-5-17-12-27-25(30-20(17)11-16)31-22-8-9-28-34(22)2/h4-14,23H,1-3H3,(H,32,35)(H,27,30,31)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM180961 (US9133187, I-104) Show SMILES CC(C)Nc1ncc2CCN(Cc2n1)C(=O)NC(CCC#N)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C21H24Cl2N6O/c1-13(2)26-20-25-11-15-7-9-29(12-19(15)27-20)21(30)28-18(4-3-8-24)14-5-6-16(22)17(23)10-14/h5-6,10-11,13,18H,3-4,7,9,12H2,1-2H3,(H,28,30)(H,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	7.3	n/a
ARRAY BIOPHARMA INC.; GENENTECH, INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9133187 (2015) BindingDB Entry DOI: 10.7270/Q28W3C2N
					More data for this Ligand-Target Pair

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