Ki Summary

Reaction Details

Report a problem with these data

Target

Cannabinoid receptor 2

Ligand

BDBM192522

Substrate/Competitor

n/a

Meas. Tech.

Radioligand Displacement Assay (CP55940)

2230±n/a nM

Citation

Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH Peripherally restricted diphenyl purine derivatives US Patent US9187480 Publication Date 11/17/2015

More Info.:

Get all data from this article, Assay Method

Cannabinoid receptor 2

Name:

Cannabinoid receptor 2

Synonyms:

CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

39690.94

Organism:

Homo sapiens (Human)

Description:

P34972

Residue:

360

Sequence:

MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILS
SHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTAS
VGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCS
ELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLD
VRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYA
LRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC

BDBM192522

n/a

Name

BDBM192522

Synonyms:

US9187480, N-{[4-({[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]amino}methyl)cyclohexyl]methyl}methanesulfonamide

Type

Small organic molecule

Emp. Form.

C26H28Cl2N6O2S

Mol. Mass.

559.511

SMILES

CS(=O)(=O)NCC1CCC(CNc2ncnc3n(c(nc23)-c2ccccc2Cl)-c2ccc(Cl)cc2)CC1 |(2,1.92,;3.33,2.69,;4.1,4.03,;2.56,4.03,;4.67,1.92,;4.67,.38,;3.33,-.39,;2,.38,;.67,-.39,;.67,-1.93,;-.67,-2.7,;-2,-1.93,;-3.33,-2.7,;-4.67,-1.93,;-6,-2.7,;-6,-4.24,;-4.67,-5.01,;-4.35,-6.51,;-2.82,-6.67,;-2.19,-5.27,;-3.33,-4.24,;-2.05,-8.01,;-2.82,-9.34,;-2.05,-10.67,;-.51,-10.67,;.26,-9.34,;-.51,-8.01,;.26,-6.67,;-5.44,-7.6,;-6.92,-7.2,;-8.01,-8.29,;-7.61,-9.78,;-8.7,-10.87,;-6.13,-10.18,;-5.04,-9.09,;2,-2.7,;3.33,-1.93,)|

Structure